Hypoxia had variable effects on expression of SIRT1, AMPK, SIRT3, and SIRT3 activity depending on the sex. The capacity of the fetal heart to respond to hypoxia differs depending on the gestational age of exposure and sex of the fetus. Further, the effects of late-onset hypoxia on fetal ...
Secondary antibodies Peptides PGC1 Peptide- #AF5395-BP Product:PGC1 Peptide Catalog:AF5395-BP Source:Synthetic Application:Blocking/Control Reactivity:Antibody available as AF5395 SizePriceInventory 1mg$350In stock Lead Time: Same day delivery ...
AMPK is known to phosphorylate Thr178 and Ser539, promoting cotranscriptional activity. Conversely, Akt-mediated phosphorylation at Ser571 is reported to downregulate PGC-1 alpha activity. This latter effect is achieved by an initial Ser571 phosphorylation, followed by GCN5 binding and subsequent ...
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α has emerged as a master regulator of mitochondrial biogenesis; furthermore, it has been shown that PGC-1alpha gene expression is induced by exercise and ... S Jager,C Handschin,J St.-Pierre,...
We investigated the ability of AMP-activated protein kinase (AMPK) to activate PPARgamma coactivator-1alpha (PGC-1alpha) in the brain, liver and brown adipose tissue (BAT) of the NLS-N171-82Q transgenic mouse model of Huntington's diseas... RK Chaturvedi,NY Calingasan,L Yang,... - ...
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1. Adiponectin is an anti-diabetic adipokine. Its receptors possess a seven-transmembrane topology with the amino terminus located intracellularly, which is t... M Iwabu,T Yamauchi,M Okada-Iwabu,... - 《Na...
Recent evidence suggests that reactive oxygen species (ROS) produced by inflammatory cells drive axonal degeneration in active multiple sclerosis (MS) lesions by inducing mitochondrial dysfunction. Mitochondria are endowed with a variety of antioxidant e
This review mainly focuses on interconnecting role of PGC-1 alpha and AMPK-SIRT1 pathway during exercise and how these proteins are getting tuned by reactive oxygen species in exercise condition.Thirupathi, Anandde Souza, Claudio TeodoroUniv Extremo Catarinense Lab Exercise Biochem &...
AMPK: AMP-activated protein kinase AS160: Akt substrate of 160 kDa COXIV: Cytochrome c oxidase subunit IV CPTI: Carnitine palmitoyltransferase 1 EDL: Extensor digitorum longus FABP: Fatty acid binding protein FAT: Fatty acid translocase PGC-1α: Peroxisome proliferator-activated receptor ga...
PGC-lalpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr Opin Lipidol. 2009; 20:98-105. [PubMed: 19276888]C. Canto, J. Auwerx, PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure, Curr. Opin. Lipidol. 20 (2009)...