Hypoxia had variable effects on expression of SIRT1, AMPK, SIRT3, and SIRT3 activity depending on the sex. The capacity of the fetal heart to respond to hypoxia differs depending on the gestational age of exposure and sex of the fetus. Further, the effects of late-onset hypoxia on fetal ...
Secondary antibodies Peptides PGC1 Peptide- #AF5395-BP Product:PGC1 Peptide Catalog:AF5395-BP Source:Synthetic Application:Blocking/Control Reactivity:Antibody available as AF5395 SizePriceInventory 1mg$350In stock Lead Time: Same day delivery ...
Molecular Genetics and Genomics - The discovery and interpretation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) protein in mitochondrial biogenesis,... 展开 关键词: PGC-1 alpha Mitochondrial biogenesis Skeletal muscle Adipose tissue Mitochondria ACTIVATED PROTEIN-KINASE COACTI...
(aa 566-710). PGC-1 alpha activity is regulated by phosphorylation. AMPK is known to phosphorylate Thr178 and Ser539, promoting cotranscriptional activity. Conversely, Akt-mediated phosphorylation at Ser571 is reported to downregulate PGC-1 alpha activity. This latter effect is achieved by an ...
Anti-phospho-AMPK alpha 1(Thr172)/Cy3 荧光素(Cy3)标记的磷酸化腺苷单磷酸活化蛋白激酶α1抗体 Anti-phospho-Kidins220(Ser919)/PE PE标记的磷酸化220kDa蛋白激酶D相互作用蛋白抗体 Anti-Phospho-CENP-A (Ser7)/FITC 荧光素(FITC)标记的磷酸化着丝粒蛋白A Anti-Phospho-Cyclin D1 (Thr286)/PE PE标记...
Tilianin Myocardial ischemia/reperfusion injury AMPK SIRT1 PGC-1α 1. Introduction Cardiovascular disease has always been one of the major diseases threatening human health with the highest morbidity and mortality and remains one of the leading cause of death in the world.1 In recent years, since...
Recent evidence suggests that reactive oxygen species (ROS) produced by inflammatory cells drive axonal degeneration in active multiple sclerosis (MS) lesions by inducing mitochondrial dysfunction. Mitochondria are endowed with a variety of antioxidant e
This review mainly focuses on interconnecting role of PGC-1 alpha and AMPK-SIRT1 pathway during exercise and how these proteins are getting tuned by reactive oxygen species in exercise condition.Thirupathi, Anandde Souza, Claudio TeodoroUniv Extremo Catarinense Lab Exercise Biochem &Journal of ...
Activating AMPK-SIRT1-PGC1 alpha pathway can improve the cognitive function and mitigate the neuronal injury in Sevo-anesthetized aged rats by antagonizing the oxidative stress and maintaining the mitochondrial function.Yang, Xiao-YuLi, Qiu-JunZhang, Wen-ChaoZheng, Shao-QiangQu, Zhi-JunXi, Yang...
AMPK: AMP-activated protein kinase AS160: Akt substrate of 160 kDa COXIV: Cytochrome c oxidase subunit IV CPTI: Carnitine palmitoyltransferase 1 EDL: Extensor digitorum longus FABP: Fatty acid binding protein FAT: Fatty acid translocase PGC-1α: Peroxisome proliferator-activated receptor ga...