Full size image Analysis of c-wave ERG revealed significantly reduced RPE function both in thePgc-1α+/−(adjusted ANOVAP = 0.0066) andPgc-1α−/−(adjP = 0.0002), compared to WT mice (Fig.1C, D). Although we observed a trend towards reduced c-waves betweenPgc-1α−...
Full size image PGC7 is highly expressed in pluripotent cells and poorly differentiated tumor tissues The expression pattern of PGC7 in the hepatocyte differentiation model was further confirmed by qRT-PCR. PGC7 reached its peak expression in the liver progenitor stage and then rapidly dropped after...
Triple-negative breast cancer (TNBC) is characterized by its high metastatic potential, which results in poor patient survival. Cancer-associated fibroblasts (CAFs) are crucial in facilitating TNBC metastasis via induction of mitochondrial biogenesis. Ho
The use of phytochemicals has unique advantages for medical applications, providing a novel approach to cancer prevention and improving patient outcomes and treatment efficacy, resulting in more effective treatment strategies. Additionally, studies have demonstrated that phytochemicals are a cost-effective opt...
(Gibco; Thermo Fisher Scientific, Inc.) as full medium at 37°C with 5% CO2. The overexpression plasmid for PGC-1α and its negative control were gifts from Professor Zhiguo Zhang (State Key Laboratory of Medical Genomics, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai ...
protein was detected by western blot analysis full size image the c-terminal ctar-2 domain of lmp1 promotes prmt1-pgc-1α interaction to enhance pgc-1α arginine methylation in order to identify the specific domain of lmp1 that promotes the prmt1-pgc-1α interaction, we predicted the complex...
Instant access to full article PDF Buy now Additional access options: Log in Learn about institutional subscriptions Read our FAQs Contact customer support References Download references Acknowledgements We thank E. Smith for assistance with graphics. We also thank our colleagues and the members of our...
(13) express no full-length PGC-1α but reveal that the mice express a slightly shorter form of NT-PGC-1α (NT-PGC-1α254). Therefore, we have designated the mice developed by Leone et al. (13) as FL-PGC-1α−/− mice to denote the specific absence of full-length PGC-1α...
Although the expression of full length PGC-1α is al- most completely extinguished in homozygous mice, they retain the potential to produce a truncated form of the protein (amino acids 1–254), named NT-PGC- 1α254, and which is functionally similar to the nat- ural sp...
(ATA). This leads to 1% translation efficiency compared to FNDC5 with canonical ATG in vitro. However, Albrecht et al. have shown in the new study that the first exon with the mutant codon is not expressed at all by RNA-seq. This prevents even the theoretical opportunity to produce full...