镰⼑型贫⾎症(Sickle cell disease,SCD)由于β珠蛋⽩基因的单碱基突变导致的,该突变合成的⾎红蛋⽩在低氧条件下极易发⽣聚集,形成多聚体,聚合的⾎红蛋⽩使红细胞呈镰⼑状,镰⼑状的红细胞极易堵塞⾎管,引起组...
The impact of six polymorphisms of PGC-1 alpha with Type 2 Diabetes (T2D) susceptibility was evaluated on 1125 samples comprising of 554 T2D cases and 571 controls among three endogamous groups (Bania, Brahmin and Jat Sikh) of North-West India (Punjab). Single-locus analysis showed a ...
4. Cho, H., Rambout, X., Gleghorn, M.L., Nguyen, P.Q.T., Phipps, C.R., Miyoshi, K., Myers, J.R., Kataoka, N., Fasan, R., and Maquat, L.E. (2018). Transcriptional coactivator PGC-1alpha contains a novel C...
LIU R,LI J L,LV X B.Association of PGC-1αgene w ith intramuscular fat content and muscle fiber traits and gene expression in Tibetan pigs.Journal of Animal and Veterinary Advances. 2011Liu, R.,Li, J. L.,Lv, X. B.. Association of PGC-1 alpha gene with intramuscular fat content ...
drug为给药组GAPDH内参基因的循环数,CtPGC-αgene. NS为给生理盐水组PGC-1α基因的循环数,CtGAPDHgene.NS为生理盐水组GAPDH内参基因的循环数。 2.8 数据分析 实验结果的数据以±s表示。应用Microsoft Excel软件中t检验方法进行统计学分析,P0.05表示有统计学意义。 3 结果 3.1 药材提取物对KM小鼠肺部组织中PGC-1...
该PGC1 alpha Polyclonal Antibody. The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact ...
Conclusions:These results suggest that PGC-1α promotes the recruitment of polymerase II to the PGC-1α target gene promoters. Downregulation of PGC-1α target genes in the failing heart is attributed, in part, to a reduction of the PGC-1α occupancy and the polymerase II recruitment to the...
significant decrease in mitochondrial gene expression and in respiration, and YY1 was required for rapamycin-dependent repression of those genes. Moreover, mTOR and raptor interacted with YY1, and inhibition of mTOR resulted in a failure of YY1 to interact with and be coactivated by PGC-1alpha....
We investigated the role of PGC-1α in regulating the susceptibility of RGCs to metabolic and oxidative damage in wild-type (WT) and PGC-1α–knockout mice, and observed significant effects on RGC survival and on target gene expression. We observed similar gene expression changes in PGC-1α...
3-1 Mutation of PGC-1alpha affects neurite outgrowth 15 3-2 Mutation of PGC-1alpha alters the promoter activity of NRF-1 downstream gene 16 3-3 Mutation of PGC-1alpha alters the promoter activity of PPAR downstream gene 17 &...