Endothelial dysfunction is a characteristic of many vascular related diseases such as hypertension. Peroxisome proliferator activated receptor gamma, coactivator 1α (PGC-1α) is a unique stress sensor that largely acts to promote adaptive responses. The
162 PGC-1alpha correlates with cardiac and skeletal muscle oxidative capacity in heart failureNo abstract is available for this article.doi:10.1016/S1567-4215(03)90091-9A GARNIERD FORTINC DELOMENIEI MOMKENR VENTURACLAPIEREuropean Journal of Heart Failure Supplements...
26, we next examined its expression in the liver of HFD mice. The treatment of NHP markedly increased the protein abundance of PGC-1α in the liver of HFD mice (Fig.5a). The mRNA expression ofPgc-1αwas also upregulated by NHP (Fig.5b). Palmitic acid (PA) incorporation in ...
Atherosclerosis Supplements Volume 3, Issue 2, October 2002, Pages 105PPARGC1/PGC1 gene locus: Associations with obesity indices and diabetes risk: , H. Oberkofler, V. Linnemayr, B. Iglseder, M. Hedegger, P. Wolfsgruber, B. Paulweber, G. Fastner, F. Krempler, W. Patsch. Landes...
1. Introduction In cardiac myocytes, as in other metabolically active cells, peroxisome proliferator-activated receptor (PPAR) gamma coactivator 1-alpha (PGC-1α) is an essential factor promoting gene expression pathways that support cellular energy production [1]. Downregulation of cardiac PGC-1α ...
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PGC1 alphaAntioxidant enzymesBackground and aim: SIRT1 and PGC1 alpha are two important genes, which play critical roles in regulating oxidative stress and inflammation processes. The study aimed assess the effects of coadministration of omega-3 and vitamin E supplements on SIRT1 and PGC1 alpha...
Signaling through mTORC1, as reflected in p70S6 kinase phosphorylation, was stimulated to a greater extent by the EAA and BCAA than the leucine or placebo supplements. Unexpectedly, intake of EAA or BCAA attenuated the stimulatory effect of exercise on PGC-1alpha4 expression by ~50% (from a ...
doi:10.1016/S1744-1161(08)70064-4R. Barazzoni and M. Zanetti and M. Cattin and A. Semolic and A. Pirulli and P. Vinci and M. Stebel and E. Codarin and L. Cattin and G. GuarnieriClinical Nutrition Supplements