In TLR signaling, PGAM5 regulates the expression and production of inflammatory cytokines by regulating the activation of downstream signaling pathways, including the NF-魏B and MAPK pathways. Upon LPS stimulation, PGAM5 interacts with Drp1 to form a complex, leading to the prod...
10. Therefore, we next tested whether Drp1 contributes to RIPK3-PGAM5-mediated inflammatory cytokine expression in NKT cells. Drp1 activity and translocation to the mitochondria is regulated by dephosphorylation. We
Western blot检测细胞质基质中Pgam5和Drp1蛋白表达水平.结果:与正常细胞比较,尿酸干预组细胞活力显著降低,凋亡率显著升高,线粒体肿胀,空泡化,嵴断裂,线粒体中Pgam5的m RNA表达显著降低,而细胞质基质中Pgam5和Drp1的蛋白表达水平显著升高(P<0.01).结论:尿酸可破坏肾细胞线粒体结构,上调细胞质基质中Pgam5/Drp1表达...
ARTICLE Received 16 Mar 2015 | Accepted 13 Aug 2015 | Published 18 Sep 2015 DOI: 10.1038/ncomms9371 OPEN Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling Young Jun Kang1, Bo-Ram Bang1, Kyung Ho Han2, Lixin Hong1, ...