在健康细胞中,Stx17 的 C 端疏水结构域(CHD)与 PGAM5 的跨膜结构域结合,调节线粒体蛋白磷酸酶 PGAM5 的定位,促进 Drp1 去磷酸化和线粒体分裂。在 PINK1/Parkin 介导的线粒体自噬过程中,Stx17 释放 PGAM5,促进在线粒体自噬应激下 FUNDC1 的去磷酸化。除了对 Drp1 的直接作用外,PGAM5 还使 FUNDC1 去...
Upon mitochondrial dysfunction, PGAM5 recruits and dephosphorylates Drp1 at Ser-637, triggers its GTPase activity and promotes mitochondrial fission. PGAM5 regulates mitophagy by stabilizing PINK1 under stress conditions, which recruits E3 ubiquitin ligase PARKIN for degradation of the damaged mitochondria...
PGAM5 regulates PINK1/Parkin-mediated mitophagy via DRP1 in CCCP- induced mitochondrial dysfunction Toxicol. Lett., 284 (2018), pp. 120-128, 10.1016/j.toxlet.2017.12.004 View PDFView articleView in ScopusGoogle Scholar Remijsen et al., 2014 Q. Remijsen, V. Goossens, S. Grootjans, C....
Upon mitochondrial dysfunction, PGAM5 recruits and dephosphorylates Drp1 at Ser-637, triggers its GTPase activity and promotes mitochondrial fission. PGAM5 regulates mitophagy by stabilizing PINK1 under stress conditions, which recruits E3 ubiquitin ligase PARKIN for degradation of the damaged mitochondria...
PGAM5 is cleaved within the TM domain in response to the loss of the mitochondrial membrane potential (Δψm) in the initial step of PINK1-Parkin-dependent mitophagy and released from mitochondria depending on proteasome-mediated rupture of the outer mitochondrial membrane (OMM). Released cleaved ...
domain of PGAM5, regulating the localization of the mitochondrial protein phosphatase PGAM5 to promote Drp1 dephosphorylation and mitochondrial fission. In response to PINK1/Parkin-mediated mitophagy, Stx17 releases PGAM5, promoting the dephosphorylation of FUNDC1 in response to mitochondrial autophagic ...
In healthy cells, loss of Stx17 causes PGAM5 aggregation within mitochondria and thereby failure of the dephosphorylation of Drp1, leading to mitochondrial elongation. In Parkin‐mediated mitophagy, Stx17 is prerequisite for PGAM5 to interact with FUNDC1. Our results reveal that the Stx17‐PGAM5 ...
domain of PGAM5, regulating the localization of the mitochondrial protein phosphatase PGAM5 to promote Drp1 dephosphorylation and mitochondrial fission. In response to PINK1/Parkin-mediated mitophagy, Stx17 releases PGAM5, promoting the dephosphorylation of FUNDC1 in response to mitochondrial autophagic ...
Upon mitochondrial dysfunction, PGAM5 recruits and dephosphorylates Drp1 at Ser-637, triggers its GTPase activity and promotes mitochondrial fission. PGAM5 regulates mitophagy by stabilizing PINK1 under stress conditions, which recruits E3 ubiquitin ligase PARKIN for degradation of the damaged mitochondria...
PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol 2018, BMC Biology Show abstract PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis 2020, Autophagy New roles for mitochondrial proteases in health, ageing and disease ...