Per- and polyfluoroalkyl substances (PFAS) are environmental contaminants with various adverse health effects in humans including disruption of lipid metabolism. Aim of the present study was to elucidate the molecular mechanisms of PFAS-mediated effects on lipid metabolism in h...
Unfavorable developmental or neurobehavioral effects on humans of prenatal exposure to PFAS were reported by Donauer et al. [50] (hypotonic babies at 5 weeks of age) and Hoyer et al. [51] (hyperactivity and behavioral problems in children). However, not all studies observed adverse effects. ...
The potential endocrine disrupting effects of different long and short chain PFAS on humans are largely unknown. There is evidence suggesting that rise in obesity is correlated with the significant increase in the number of industrial chemicals including PFAS available on the market (Baillie-Hamilton,...
This review focuses on PFAS-induced neurological effects, highlighting disrupted dopamine signalling and structural neuron changes in humans. Animal studies reveal apoptosis and hippocampus dysfunction, resulting in memory loss and spatial learning issues. The review introduces the BKMR model, a machine ...
Abstract Per- and polyfluoroalkyl substances (PFAS), commonly referred to as “forever chemicals” raise significant concerns due to their persistence, bioaccumulation potential and toxicity. However, there is limited information on the occurrences of PFAS in surface water in the Western United States...
The US Environmental Protection Agency (EPA) estimates there are more than14,700 known chemicalswithin the PFAS family. Not all PFAS are toxic, but only a fraction of the compounds are well-studied and understood. Today, it’s widely accepted that many PFAS pose a health risk to humans, an...
Although efforts have been made to substitute long-chain PFAS towards safer alternatives, their persistence in humans still leads to exposure to these compounds. PFAS immunotoxicity is poorly understood as no comprehensive analyses on certain immune cell subtypes exist. Furthermore, mainly single ...
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) have been used in various industries for decades. Some are potentially harmful to both humans and the environment. While some are completely harmless, such as PTFE. The proposed ban would have great Impact on the sealing industry, as PTFE is ...
83. Elevated PFAS levels in biota are indicative of widespread environmental contamination, which can have cascading effects on wildlife health, ecosystem dynamics, and even potential risks to humans. Besides, our findings align with other studies, collectively highlighting the widespread presence and ...
As well as drinking PFAS through water supplies, there are a wide array of other ways in which humans can become exposed to the chemicals. That’s due to the fact that PFAS are both highly mobile and incredibly persistent, meaning they can permeate all kinds...