Given that PFAS exposure in humans primarily occurs through food intake, we initiated a cohort study in collaboration with various medical specialists to understand and address the actual situation of PFAS exposure in Japanese individuals who consume seafood with relatively high PFAS concentrations. The ...
Among the thousands of PFAS compounds, PFOA and PFOS have been the most extensively used and studied. Despite their phase out in the early 2000s, these PFAS as well as others that were not discontinued remain highly detectable across the global population due to their persistence and bio-accumu...
The mechanisms that elucidate the hypocholesterolemic effect of PFAs could be linked to the diminished activity of enzymes that play a role in lipid metabolism, such as 3-hydroxy-3-methylglutaryl-CoA reductase (an enzyme related to cholesterol synthesis), cholesterol-7 hydroxylase, fatty acid ...
PFAS could be detected in the PluriBeat assay. Considering thatorganogenesisis perceived the most sensitive period of early development and that the heart is the first organ to form during development (Bulatovic et al., 2016), we hypothesized thatembryotoxicityof PFAS would be evident in this ...
Direct exposures due to use in products can be quickly phased out by shifts in chemical production but exposures driven by PFAS accumulation in the ocean and marine food chains and contamination of groundwater persist over long timescales. Serum concentrations of legacy PFASs in humans are ...
PFHxA, the DBP 1,1,1-trichloropropanone, and the herbicide 2,4-dichlorphenoxyacetic acid (2,4–D) were common drivers of ∑EAR-MED in public–TW, with additional contributions by a range of VOC, pesticide and pesticide–degradate, and PFAS compounds. Butanol (3 samples) and isopropanol ...
Memantine is used for the treatment of moderate to severeassociated with Alzheimer's. Dementiacan be categorized into three levels of severity: mild in which patients are alert and sociable, but forgetfulness begins to interfere with daily living, moderate which often is the longest stage of the ...
More than 4000 PFAS have been identified and levels of some PFAS bioaccumulate in humans [2]. Previous studies have linked prenatal PFAS exposure to increased risk of adverse pregnancy outcomes. For example, increased concentrations of perfluorooctanoic acid (PFOA), perflucorooctane sulfonic acid (...
Andersen ME, Hagenbuch B, Apte U, Corton JC, Fletcher T, Lau C et al (2021) Why is elevation of serum cholesterol associated with exposure to perfluoroalkyl substances (PFAS) in humans? A workshop report on potential mechanisms. Toxicology 459:152845 CAS PubMed Google Scholar Anderson-Maho...
Early investigation into the effects of diet on serum cholesterol showed that vegetable oils were hypocholesterolemic when substituted for saturated fatty acids. Subsequent work by many investigators seemed to indicate that polyunsaturated fats (PFAs) were cholesterol-lowering, saturated fats (SFAs) were...