Peutz-Jeghers syndrome is an autosomal dominant condition leading to gastrointestinal polyps which often causes bowel obstruction. This syndrome also predisposes to gastrointestinal, pancreatic, breast, uterine and other malignancies. Prognosis is likely to be improved by the early commencement of ...
The meaning of PEUTZ-JEGHERS SYNDROME is a familial polyposis inherited as an autosomal dominant trait and characterized by numerous polyps in the stomach, small intestine, and colon and by melanin-containing spots on the skin and mucous membranes especi
Peutz-Jeghers综合征(Peutz-Jeghers syndrome, PJS)是一种由LKB1/STK11胚系突变引起的、以皮肤黏膜黑斑和胃肠道错构瘤息肉为特征的常染色体显性遗传病[1-3]. 黑斑一般无需特殊治疗; 而胃肠道息肉可继发出血、梗阻、肠套叠、恶变等多种严重并发症, 且具有发病年龄早、诊治困难、病程迁延的特点[4-6]. 对患者及其...
Peutz-Jeghers syndrome is autosomal dominant, meaning that the mutation that causes it is not on one of the sex-linked chromosomes (X and Y) and that one copy of the defective gene, received from either parent, is enough to cause the disorder. The genetic defect can also arise in someone...
Peutz-Jeghers (PJ) syndrome is an autosomal-dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous pol... DE Jenne - 《Nature Genetics》 被引量: 3179发表: 1998年 Very high risk of cancer in familial Peutz-Jeghers syndrome. Background & Aims:...
Peutz-Jeghers (PJ) syndrome is an autosomal-dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous pol... DE Jenne - 《Nature Genetics》 被引量: 3179发表: 1998年 Very high risk of cancer in familial Peutz-Jeghers syndrome. Background & Aims:...
Peutz-Jeghers Syndrome - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the Merck Manuals - Medical Professional Version.
Synonym(s) None Definition Hereditary syndrome characterized by multiple gastrointestinal polyps and mucocutaneous pigmentation Pathogenesis Autosomal dominant trait; germline mutation of STK11 (serine threonine kinase 11) gene; protein likely regulated by phosphorylation by cAMP -dependent protein kinase A ...
Peutz-Jeghers Syndrome is an autosomal dominant syndrome characterized by hamartomatous gastrointestinal polyps and mucocutaneous melanin pigmentation. Patients are also at risk for extraintestinal neoplasms. In this chapter, the clinicopathologic characteristics of the syndrome, its management and surveillance ...
Peutz-Jeghers (PJ) syndrome is an autosomal-dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous pol... DE Jenne,H Reomann,JI Nezu,... - 《Nature Genetics》 被引量: 2345发表: 1998年 Jenne, D. E. et al. Peutz-Jeghers syndrome is cause...