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V denotes a scalar and represents the maximum value of the evaluated image \({\varvec{x}}\). $$\begin{array}{*{20}c} {SSIM = \frac{{\left( {2\mu_{{\varvec{x}}} \mu_{{{\varvec{x}}_{{\varvec{r}}} }} + a_{1} } \right)\left( {2\sigma_{{{\varvec{x}},{\...
We tested dual-target PET/MR imaging at two time points after acute MI. The first imaging occurred on day 2 after coronary ligation, which coincides with the inflammatory phase characterized by an abundance of inflammatory neutrophils, monocytes and macrophage subsets (Fig. 6a). The second imaging...
Image-derived input function One emerging example of the application of high-resolution and high-sensitivity total-body small animal PET is to obtain the noninvasive IDIF for kinetic modeling. Kinetic modeling with dynamic PET provides sophisticated quantitation of the tracer kinetics with improved prog...
value (SUV) measurements [98,99,100]. The arterial input function, which describes the time-activity curve of the radiotracer in the blood, is a prerequisite for kinetic modeling. The input function can be derived using arterial blood sampling, which is the conventional method [101]. However...
[50], the simulation of high-resolution digital phantom (DP) and PET images (simFBP) was performed using segmented MRI as the input. For DP generation, each voxel was assigned a specific intensity value according to tissue type-specific distributions observed from actual FBP SUVR images across...
Two cases of Takayasu arteritis (TA) were reported by Tarkin et al. [15] where [18F]FDG PET proved useful in diagnosing TA but more limited in value for tracking therapeutic responses or detecting residual arteritis. SSTR PET/MRI accurately identified the lesions in both cases suggesting potent...
(λ) controls the amount of regularization applied to the model. When lambda is large, coefficients for variables with smaller absolute values are compressed to zero. We applied a 10-fold cross-validation method to identify the optimal value of λ, which minimized the mean cross-validation error...