Sasaki K, Maikusa N, Imabayashi E, Yuasa T, Matsuda H. The feasibility of 11C-PIB-PET/CT for amyloid plaque burden: valida- tion of the effectiveness of CT-based partial volume correction. Brain Behav. 2016;6:e00532. https://doi.org/10.1002/brb3.532....
PETSPECTHomogenate bindingAmyloid plaqueBrain imagingIn vivo imaging of amyloid plaques may be useful for evaluation and diagnosis of Alzheimer's disease (AD... MP Kung,C Hou,ZP Zhuang,... - 《Brain Research》 被引量: 364发表: 2004年 Radioiodinated aza-diphenylacetylenes as potential SPECT im...
Then a voxel on PET imaging containing amyloid activity can be segmented into the volume fraction for amyloid plaque (f v), which has differential uptake ratio D, and the volume fraction without plaque (1 − f v), which has unit background activity. The total activity concentration (...
According to Thal amyloid phase, pons and cerebellum are among the latest regions presenting amyloid pathology in AD11. The cerebellum has been used as a reference region in most previous studies using [C-11] Pittsburgh compound B (PiB) PET scans2,4,12. However, there is concern that cerebe...
We have previously established that total Aβ, measured by ELISA, closely matches Aβ plaque load as determined with immunohistochemistry in tg-ArcSwe mice27. There was a significant difference in brain retention of the fusion protein between tg-ArcSwe and WT mice at 12 months (3.5-fold) and...
Imaging of amyloid β in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism - ScienceDirect Amyloid-β (Aβ) plaque formation is a hallmark of Alzheimer's disease (AD) and precedes the onset of dementia. Aβ imaging should allow earlier diagnosis,... ...
COC before and after the scan, we used multiple regression models adjusting for participant age, sex, race, education, cognitive function (TICS-M), general health status, the Charlson Comorbidity Index, and included an indicator for scan result (elevated vs. not elevated amyloid plaque level)....
In all cases, a fluorescent version of PiB was applied directly to brain tissue postmortem to determine the binding pattern and then compared to immunohistochemical stains for beta amyloid. In one case, an individual subject had undergone a PiB PET scan within 10 months of death, permitting a ...
The β-amyloid burden (percentage of gray matter containing β-amyloid aggregates) was calculated for each tissue section. The value for each anatomical region was based on the mean obtained using values from all slides from that region (Figure). β-Amyloid neuritic plaque density was determined...
P2‐245: A PRE‐PIVOTAL STUDY: B‐AMYLOID PLAQUE DETECTION IN THE LENS OF THE EYE IN MCI AND MILD AD ‐ CORRELATON WITH AMYLOID PET SCANNINGdoi:10.1016/j.jalz.2019.06.2652Carl H. SadowskyDaniel R. VlockTersea VillenaDennis Nilan