[23] Zhang W, Kung M P, Oya S, et al. 18F-labeled styrylpyridines as PET agents for amyloid plaque imaging[J]. Nucl Med Biol, 2007, 34(1): 89-97. [24] Clark C M, Pontecorvo M J, Beach T G, et a...
Information on the market implications of the CMS decision is provided. In June 2012, Eli Lilly requested CMS coverage of PET for amyloid plaque detection using Amyvid. Jo Ellen Slurzberg of JR Associates explains the dilemma posed by the request to CMS.EBSCO_AspMedical Device Daily...
standardizing quantitative amyloid plaque estimation by pet[j]. alzheimers dement, 2015, 11(1): 115.e1e4. doi: 10.1016/j.jalz.2014.07.003. [81] chen k, roontiva a, thiyyagura p, et al. improved power for characterizing longitudinal amyloidβ pet changes and evaluating amyloid...
β-淀粉样蛋白(amyloid β-protein,Aβ)、Tau蛋白是AD的重要病理标志物。PET及相应的正电子探针被广泛应用于AD的研究,通过选用不同的PET正电子探针,可以全面、准确地反映神经递质受体改变、特殊病理标志物出现等一系列AD病理特征,从而在AD的鉴别诊断和...
PETSPECTHomogenate bindingAmyloid plaqueBrain imagingIn vivo imaging of amyloid plaques may be useful for evaluation and diagnosis of Alzheimer's disease (AD... MP Kung,C Hou,ZP Zhuang,... - 《Brain Research》 被引量: 364发表: 2004年 Radioiodinated aza-diphenylacetylenes as potential SPECT im...
Here we present a PET ligand to be used for diagnosis and evaluation of treatment effects in Alzheimer’s disease. The amyloid β (Aβ) antibody mAb158 is radiolabelled and conjugated to a transferrin receptor antibody to enable receptor-mediated transcytosis across the BBB. PET imaging of two...
Drzezga, A.et al. Effect ofAPOEgenotype on amyloid plaque load and gray matter volume in Alzheimer disease.Neurology72, 1487–1494 (2009). ArticleCASPubMedGoogle Scholar Reiman, E. M.et al. Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer'...
虽然大多数研究表明,阿尔茨海默病(Alzheimer’s diease, AD)是由淀粉样蛋白(amyloid-β,Aβ)沉积和淀粉样斑块(amyloid plaque)病理学触发的,但tau病理学与认知功能下降和神经元丢失的关联性更强。目前,AD尚缺乏关于tau病理学良好的流体生物标志物,而且评价脑脊液中p-tau与tau PET显像相关性的研究结果存在相互矛盾。
PET imaging of amyloid with Florbetapir F 18 and PET imaging of dopamine degeneration with 18F-AV-133 together distinguish Alzheimer's disease from DLB pat... Background DLB and AD are frequently confused in clinical practice. Amyloid pathology is required for a diagnosis of AD and is often fo...
要注意的是,尽管淀粉样蛋白PET可以有效地鉴别大部分非AD病理的痴呆类型,但混合型AD及一些其他神经系统疾病也出现明显的淀粉样蛋白沉积,例如脑淀粉样血管病(cerebral amyloid angiopathy,CAA)、部分DLB和帕金森病痴呆(Parkinson′s disease d...