cancer cell 2-hydroxyglutarate production remains to be established, it is quite likely that this pool of protein has the potential to affect the activity of chromatin-modifying enzymes (and hence themethylationstatus of chromatin). Relatedly, cartilage-specific IDH1R132Qknock-in mice and mice ...
The marker enzyme of the peroxisome—a phylogenetically old yet only recently discovered cell organelle—is catalase, a hemoprotein which decomposes hydrogen peroxide catalatically as well as peroxidatically. In the peroxisomes, catalase is associated with H2O2-producing oxidases and other enzymes....
a highly potent hypolipemic drug, show only very weak peroxisome proliferation in guinea pigs liver and human hepatoblastoma cell line (HepG2), in contrast to treated rats liver in vivo and to rat hepatoma cell line (Fao).Supported by GIS Toxicologie Cellulaire de Dijon and Conseil Regional ...
However, it presents the eukaryotic cell with the problem of targeting proteins to their specific location (s). Proteins must be efficiently transported from their site of synthesis in the cytosol to their specific organelle (s). Such a process may require translocation across one or more ...
Both signals have been integrated in subcellular location prediction programs. However their present performance, particularly of PTS2-targeting did not seem fitting for large-scale screening of sequences.DOI: 10.1186/1471-2105-9-S12-S16 被引量: 31 ...
d, The GFP and mCherry intensities of each of the surrounding 17x17 pixels of the peroxisome centroid location are extracted. The intensities of centroid pixel boxed in c are shown in d. Using the equation in e, the intensity fluctuations, δF(t), relative to the mean intensity are ...
Reversible protein phosphorylation is known to promote protein–protein interactions, to induce changes in the subcellular location or stability of proteins, and/or to modulate catalytic activity [7], [10]. Approximately 30% of all proteins in the human and 75% of the proteins in the yeast ...
ACBD2/ECI2-Mediated Peroxisome-Mitochondria Interactions in Leydig Cell Steroid Biosynthesis Papadopoulos, Acbd2/eci2-mediated peroxisome- mitochondria interactions in leydig cell steroid biosynthesis. Mol Endocrinol 30, 763-782 (2016)... Fan,Jinjiang,Issop,... - 《Molecular Endocrinology》 被引量:...
The import of most intraperoxisomal proteins is mediated by peroxisome targeting signals at their C-termini (PTS1) or N-terminal regions (PTS2). Both signals have been integrated in subcellular location prediction programs. However their present performa
The peroxisome proliferator-activated receptor γ specific agonists 15-deoxy-Δ12,14 -prostaglandin J2 , troglitazone, and rosiglitazone dose-dependently inhibited cell proliferation in four melanoma cell lines, whereas a specific agonist of peroxisome proliferator-activated receptor α had no such effect...