Edwards SM, Kote-Jarai Z, Meitz J, et al. Two percent of men with early-onset prostate cancer harbor germline mutations in the BRCA2 gene. Am J Hum Genet 2003;72:1.Boetes C. Update on screening breast MRI in high-risk women. Magn Reson Imaging Clin N Am. 2010; 18 :241–247. ...
Prostate cancer Diagnosis Prostate-specific antigen Percent free PSA Chinese population ROC curve 1. Introduction Prostate cancer (PCa) is the second-most frequently diagnosed malignancy in men globally [1]. Although the incidence of PCa in China is much lower than in Western countries [2], PCa ...
However, the molecular basis for the lower percent of free PSA in patients with prostate cancer remains unknown, and considerable overlap in values exists. We examined this hypothesis in men with recurrent or persistent cancer after radical prostatectomy. These men, who have "pure" cancer in that...
Patients with prostate cancer may have more of the complexed form of prostate-specific antigen (PSA) in the serum, whereas patients with benign prostatic hyperplasia have less of this complexed form and thus a higher proportion of the free form. However, the molecular basis for the lower ...
Within a PSA range of 4.1 to 10.0 ng/mL, the objective is to eliminate unnecessary negative prostate biopsies (improve specificity) without compromising cancer detection. In a screening population, Keetch and associates43 determined that 20% of men with a PSA value between 4.1 and 10.0 ng/mL ...
For the past year, Mark Shanahan has been working on “Mr. 80 Percent,” a feature story and six-episode podcast miniseries about his experience with prostate cancer. It’s a deeply personal, sometimes harrowing, often funny tale about a disease that affects millions of men. The heroes are...
Percent free prostate-specific antigen (PSA) is an accurate predictor of prostate cancer risk in men with serum PSA 2.5 ng/mL and lower. BACKGROUND.Up to 17% of men with a prostate-specific antigen (PSA) level below the accepted prostate biopsy cutoff of 2.5 ng/mL may have prostate cance...
Greater Percent-free Testosterone Is Associated With High-grade Prostate Cancer in Men Undergoing Prostate BiopsyObjective To analyze the serum androgen concentrations in men who underwent an initial prostate biopsy, focusing on the percent-free testosterone (%FT) as a predictor of low- and high-...
Knowledge and beliefs among brothers and sons of men with prostate cancer Results. Of 139 participants (age 53 卤 9 years), 92% were white, and 27% had more than one relative with prostate cancer. Ninety-eight percent of... L Cormier,L Kwan,K Reid,... - 《Urology》 被引量: 69发表...
(17):1156–61, 1991) dramatically altered the diagnosis and management of this disease. PSA correlated directly with prostate cancer risk and, therefore, was a relatively sensitive test to identify men at risk. However, it became rapidly apparent that PSA had a limited specificity. Numerous non...