Three types of chemical entities, namely, small organic molecules (organics), peptides, and biologics, are mainly used as drug candidates for the treatment of various diseases. Even though the peptide drugs are known since 1920 in association with the clinical use of insulin, only a limited ...
页数:320 译者: 出版时间:2008-10 价格:$ 157.07 装帧: isbn号码:9781588299901 丛书系列: 图书标签: Peptide-based Drug Design 2024 pdf epub mobi 电子书 图书描述 Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. In Pe...
求翻译:the number of peptide-, protein-, and antibody-based drugs是什么意思?待解决 悬赏分:1 - 离问题结束还有 the number of peptide-, protein-, and antibody-based drugs问题补充:匿名 2013-05-23 12:21:38 肽,蛋白质和抗体为基础的药物的数量 匿名 2013-05-23 12:23:18 多肽、蛋白质、抗体...
Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. In Peptide-Based Drug Design: Methods and Protocols, expert researchers provide a handbook which offers a selection of research and production tools suitable for transform...
The suite of currently used drugs can be divided into two categories traditional small molecule drugs with typical molecular weights of <500 Da but with oral bioavailability, and much larger biologics typically >5000 Da that are not orally bioavailable and need to be delivered via injection. Due ...
Peptide-based drugs have garnered much attention because of their high potencies of action and relatively few off-target side-effects52,53. Here, the newly designed peptide TAT-Y127WT effectively inhibits PP2Ac-mediated response as a competitive mimic peptide against Tyr127 nitration. Importantly,...
between cancerous cells and normal cells to trigger the process of self-assembly and release of drugs to control cell fate [31], [32], killing the cancerous cells while sparing the normal cells [33]. Therapeutics can be loaded by peptides through employing physical encapsulation or covalent ...
Solubility: Drugs must be soluble in blood to achieve prolonged circulation following systemic administration. Hydrophobic drugs with low aqueous solubility can be administered systemically by combining them with surfactants; however, these surfaces often pose health risks [30]. An alternative is to seque...
Drugs effectively preventing the devastating progression of Alzheimer's disease will be of immediate use in patients with preclinical as well as symptomatic Alzheimer's disease. The forecast is that in 2050 more than 1% of the global population will be living with Alzheimer's disease (Brookmeyer R...
Peptide-based drugs are becoming an important component of the pharmaceutical drug market, especially since new techniques have been developed in recent years to improve production, reduce metabolic breakdown, and introduce alternative routes of administration. Peptides are generally considered to have low...