Three types of chemical entities, namely, small organic molecules (organics), peptides, and biologics, are mainly used as drug candidates for the treatment of various diseases. Even though the peptide drugs are known since 1920 in association with the clinical use of insulin, only a limited ...
(p8) Currently, more than 100 peptide-based drugs have been approved by the US Food and Drug Administration (FDA), with many more in development, targeting a range of applications, including immunosuppression, antimicrobial and antiviral therapies, and cancer treatment.(p9) Despite these ...
Peptide lipidation is also a promising strategy to improve pharmacokinetic and pharmacody- namic profiles of peptide-based drugs. Self-adjuvanting peptide-based vaccines commonly utilise the powerful TLR2 agonist PamnCys lipid to stimulate adjuvant activity. The chemical synthesis of lipidated peptides ...
37,38]). Following the application of insulin in 1921, over 80 peptide drugs have since been approved, with more than 170 currently undergoing clinical trials [39]. Historically, small molecules have dominated the drug market, as they possess several beneficial features that...
The suite of currently used drugs can be divided into two categories traditional small molecule drugs with typical molecular weights of <500 Da but with oral bioavailability, and much larger biologics typically >5000 Da that are not orally bioavailable and need to be delivered via injection. Due ...
Recently, developing peptide-based drugs to treat CNS diseases has gained increasing attention in both academics and pharmaceutical industry. However, targeting delivery of peptides to brain is one of the most challenging problems faced in the treatment of CNS diseases. After explaining the brain barr...
Peptide-based drugs have garnered much attention because of their high potencies of action and relatively few off-target side-effects52,53. Here, the newly designed peptide TAT-Y127WT effectively inhibits PP2Ac-mediated response as a competitive mimic peptide against Tyr127 nitration. Importantly,...
Nonetheless, in recent years, general strategies to tackle those shortcomings have been established, and peptides are subsequently gaining increasing interest as drugs due to their unique ability to combine the advantages of antibodies and small molecules. Macrocyclic peptides are a special focus of ...
Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. In Peptide-Based Drug Design: Methods and Protocols, expert researchers provide a handbook which offers a selection of research and production tools suitable for transform...
It is however possible to protect the drugs from this harsh environment by using gastro-resistant capsules. These devices are covered by an enteric coating which only dissolves and releases its content when the pH increases. When peptides reach the upper part of the intestine, they encounter the...