et al. Venomics: a new paradigm for natural products-based drug discovery. Amino Acids 40, 15–28 (2011). Article CAS PubMed Google Scholar Dutertre, S. et al. in Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics (ed. King, G. F.) 80–96 (Royal ...
Collagen peptide based drugs and devices, as well as their production and application methodsThe present invention is in the fields of medicinal chemistry, biotechnology and pharmaceuticals. The invention provides compositions comprising one or more collagen mimetic peptides, optionally attached to one or...
therapeutic potential for individuals with diabetes due to their roles in glucose control and metabolism. Some of the current diabetic treatments are based on peptide hormones or their modifications. Moreover, researchers are investigating new peptide-based drugs to treat both type 1 and type 2 ...
NOVEL PEPTIDE-BASED DRUGS FOR THE TREATMENT OF SONIC HEDGEHOG-DEPENDENT MEDULLOBLASTOMA Medulloblastoma, the most common pediatric maligna Hopkins,R.,M.,... - 《Drugs of the Future》 被引量: 0发表: 2015年 NOVEL PEPTIDE-BASED DRUGS FOR THE TREATMENT OF SONIC HEDGEHOG-DEPENDENT MEDULLOBLASTOMA Medu...
Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. In Peptide-Based Drug Design: Methods and Protocols, expert researchers provide a handbook which offers a selection of research and production tools suitable for transform...
The future of peptide-based drugs Chem Biol Drug Des, 81 (1) (2013), pp. 136-147 CrossrefView in ScopusGoogle Scholar 11 N. Csaba, M. Garcia-Fuentes, M.J. Alonso Nanoparticles for nasal vaccination Adv Drug Delivery Rev, 61 (2) (2009), pp. 140-157 View in ScopusGoogle Scholar ...
Compared with local injection of free drugs or systemic administration, local drug delivery through peptide-based DDSs can quickly forming a drug reservoir at target disease sites. Together with the rational design of self-assembling peptides, the stability of drugs during the long-term treatment is...
Owing to their excellent specificity, low-toxicity, rich chemical diversity and availability from natural sources, FDA has successfully approved a number of peptide-based drugs and several are in various stages of drug development. Though peptides are proven good drug candidates, their usage is ...
Peptide-based drugs have garnered much attention because of their high potencies of action and relatively few off-target side-effects52,53. Here, the newly designed peptide TAT-Y127WT effectively inhibits PP2Ac-mediated response as a competitive mimic peptide against Tyr127 nitration. Importantly,...
such peptide mimetics that are useful in the synthesis of peptide-based drugs, fluoroalkene (CHCF), trifluoroethylamine, and CF3-(E-alkene) isosteres have attracted much attention since these peptide isosteres have comparable charge distribution and dipole moments as those of the amide bonds.66–...