此外,相对于抗体来说,低分子量的多肽可以实现对组织的有效渗透,从而产生更好的抗肿瘤效果。 PDC 中使用的肽可分为两类:细胞穿透肽 (cell-penetrating peptides,CPPs) 和细胞靶向肽 (cell-targeting peptides,CTPs)。CPPs 跨细胞膜的摄取机制尚未完全清楚。由于...
3.3Tumor targeting peptides Tumor targeting peptides target surface receptors on tumor cells; Like the RGD peptide, which has Arg-Gly-Asp sequence, and is able to detect theintegrin receptorson the cancer cell membrane in breast cancer cells, brain tumors, lung cancer cells andovarian carcinomace...
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Peptide therapeutics: targeting the undruggable space. Eur. J. Med. Chem. 94, 459–470 (2015). CAS PubMed Google Scholar Kintses, B. et al. Phylogenetic barriers to horizontal transfer of antimicrobial peptide resistance genes in the human gut microbiota. Nat. Microbiol. 4, 447–458 (...
Finol-Urdaneta RK, Belovanovic A, Micic-Vicovac M, Kinsella GK, McArthur JR, Al-Sabi A (2020) Marine toxins targeting Kv1 channels: pharmacological tools and therapeutic scaffolds. Mar Drugs 18 Google Scholar Frénal K, Xu CQ, Wolff N, Wecker K, Gurrola GB, Zhu SY, Chi CW, Possani...
which mainly act as agonists97,98,99,100. In addition, peptides targeting transforming growth factor (TGF)-β1101or epidermal growth factor receptor (EGFR)102, and peptide antagonists that disrupt the fibroblast growth factor (FGF)-1-FGFR1 interaction103are good examples of peptide drugs discovered...
Radiolabelled receptor-binding peptides targeting receptors (over)expressed on tumour cells are widely under investigation for tumour diagnosis and therapy
The use of CPPs in drug delivery has shown promising results in targeting specific cells and tissues, reducing off-target effects, and improving drug bioavailability. As a result, pharmaceutical companies are increasingly incorporating CPPs into their drug development pipelines to improve the delivery ...
Qureshi A, Thakur N, Tandon H, Kumar M: AVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses. Nucleic Acids Res. 2014, 42: D1147-D1153. Article PubMed Central PubMed CAS Google Scholar Gautam A, Chaudhary K, Kumar R, Sharma A, Kapoor P...
Targeting Ras isoforms directly has proven difficult historically, although some progress has been made recently (2, 3, 4). Cdc42, together with Rac1, RhoA, and other members of the Rho family small GTPases, is a key regulator of the actin cytoskeleton and therefore cell architecture and ...