Disclosed is a synthetic, non-naturally occurring 12-amino acid peptide, Lung-specific Targeting Peptide, belonging to the larger class of cell penetrating peptides, for delivery of both diagnostic and potentially therapeutic agents to the lung. Also disclosed are methods of treating pulmonary disease...
Lung cancer targeting peptide LLC: Lewis lung carcinoma LMH: Layered metal hydroxide MFM: Multifunctional micelle MMAD: Mass median aerodynamic diameter MWCNT: Multi-walled carbon nanotube Nos: Noscapine NSCLC: Non-small cell lung cancer OVs: Oncolytic viruses PAA: Poly(acrylic) acid ...
Active tumor targeting can be achieved by conjugating different tissue-specific groups and ligands including antibodies, peptides, aptamers and vitamins to nanoparticles surface26,27,28,29,30,31,32. Therefore, targeted drug delivery using targeting ligands have been developed in order to target overexp...
The opening of the immunotherapy era brings new hope to lung cancer patients. ICIs targeting programmed cell death protein 1 (PD1) or programmed cell death ligand 1 (PD-L1) have been determined to be the standard of care for NSCLC. ICI is a breakthrough immunotherapy with excellent long-term...
Also, the use of targeting peptides to maximize uptake of vectors into alveolar cells or the codelivery of siRNA with other therapeutic agents may further improve the therapeutic outcomes. Innovative nebulization technologies are also needed to improve the delivery of siRNA/carrier to the distal ...
Bone marrow mesenchymal stem cells-derived exosomal microRNA-193a reduces cisplatin resistance of non-small cell lung cancer cells via targeting LRRC1. Cell Death Dis. 2020;11(9):801. Article CAS PubMed PubMed Central Google Scholar Qin X, Yu S, Zhou L, Shi M, Hu Y, Xu X, et al...
Other inhibitors, peptides, and tumor vaccines are under preclinical and clinical studies, including MRTX849 targeting KRASG12C, MRTX1133 targeting KRASG12D, 12VC1 targeting KRASG12C/V, mRNA-5671 targeting KRASG12C/D/V, etc.[9]. In addition to targeted therapy, immunotherapies have also ...
Targeting CICs using differentiation therapy Another approach to target CICs is the induction of their differentiation, resulting in the loss of their ability for self-renewal and tumor maintenance. RA is one therapy used in the clinic to promote differentiation of epithelial cells [82]. RA-based ...
Transmembrane domain targeting peptide antagonizing ErbB2/Neu inhibits breast tumor growth and metastasis Cell Rep., 8 (2014), pp. 1714-1721, 10.1016/j.celrep.2014.07.044 View PDFView articleView in ScopusGoogle Scholar [21] J.T. O'Connell, H. Sugimoto, V.G. Cooke, B.A. MacDonald, A...
p53-activating peptides and CeO2nanoparticles, which can activate the p53 signaling pathway and down-regulate the downstream gene GPX4 in vitro and in vivo, thereby inhibiting the development and progression of lung cancer [106]. Therefore, the ferroptosis-promoting effect of targeting p53 in lung...