Peptideranker算法是一种基于机器学习的肽段活性预测和排序方法。它通过分析肽段的特征和活性关联,构建了一个肽段特征向量空间,并利用训练好的模型对待预测肽段进行评分和排序。该算法在肽段活性预测、肽段库筛选和优化等方面具有广泛的应用前景,有助于加速药物发现和生物研究的进展。©...
The PsaB protein sequence was obtained from the UniProtKB database and further investigated through PEP-UWM™, PeptideRanker, DBAASP antimicrobial peptide prediction, and ToxinPred tools to identify potential bioactive peptides. Finally, the PepDraw tool was used to obtain the peptide structures of...
The probability that the peptides identified were bioactive was predicted with the Peptide Ranker software ('in silico analysis'). This demonstrated that 70... ME Errasti,LMI Lopez - 《Journal of the Society of Leather Technologists & Chemists》 被引量: 0发表: 2024年 RetroRanker: leveraging ...
Performance of PeptideRanker measured in five-fold cross-validation on the training datasets at a threshold of 0.5.Catherine, MooneyNiall, J. HaslamGianluca, PollastriDenis C., Shields
The identified peptides were subjected to an in silico analysis by PeptideRanker algorithm in order to assign a score of bioactivity probability. Twenty-five sequenced peptides were found with potential antioxidant and angiotensin-converting-enzyme-inhibitory activities. Four of these peptides, WPRGYFL...
The aim of the study was to evaluate the potential of rice bran proteins such as glutelin, globulin, and prolamin as a precursor of bioactive peptides using various in silico approaches (BLAST, BIOPEP, PeptideRanker, PepDraw, Pepcalc, and ToxinPred). Rice bran proteins majorly release ...
Seventy-five novel ACE-inhibitory and antioxidant peptides were identified in ABGH-IV, 11 of which were predicted to be highly active based on PeptideRanker. These newly discovered peptides demonstrated stability against in vitro gastrointestinal digestion and resistance to ACE breakdown, suggesting ...
Peptide ranker showed that 14.6% and 15.7% quantified peptides from Dromedary and Bactrian has bioactivity, which were dominated by dipeptidyl peptidase IV inhibitor (39.93%), followed by ACE inhibitor (34.85%) and anti-oxidative activity (8.69%). In sum, although Dromedary and Bactrian camel ...
With relatively high scores predicted by PeptideRanker, three promising bioactive peptides, FHPFPR, NWFPLPR and NIFRPF, were further studied and their ACE inhibition effects were confirmed with IC50 values of 34.92, 16.77 and 32.40 μM, respectively. Molecular docking study provided insights into ...
Walp., using the UniProtKB, BIOPEP and PeptideRanker databases, as well as reviewing available research reports that showed evidence bioactive properties of peptides obtained from beans via in vitro assays. For all the species studied, the highest frequency of the occurrence of bioactive fragments ...