Peptideranker算法是一种基于机器学习的肽段活性预测和排序方法。它通过分析肽段的特征和活性关联,构建了一个肽段特征向量空间,并利用训练好的模型对待预测肽段进行评分和排序。该算法在肽段活性预测、肽段库筛选和优化等方面具有广泛的应用前景,有助于加速药物发现和生物研究的进展。©...
Performance of PeptideRanker measured in five-fold cross-validation on the training datasets at a threshold of 0.5.Catherine, MooneyNiall, J. HaslamGianluca, PollastriDenis C., Shields
Table S8 Potential bioactive score of significantly different peptides using peptide ranker. Table S9 The bioactivity of those potential bioactive peptides from both Dromedary and Bactrian camel using BioPEP (XLSX 1734 KB) Rights and permissions Reprints and permissions About this article Cite this ...
BIOPEP-UWM and Peptide Ranker are both restricted by allowing only peptide sequence inputs. AnOxPePred is capable of processing full protein sequences to predict embedded antioxidant peptides, but accuracy of predictions is limited by the modest size (∼1400 peptides in total) of the benchmark...
[11]. The pipeline uses ToxinPred software for toxicity prediction, Pepdite ranker for bioactivity prediction, and BBPred for predicting passage through the blood–brain barrier [21,22,23]. Peptides with a score of 0.8 or higher were considered for subsequent molecular docking analysis. Molecular...
The PsaB protein sequence was obtained from the UniProtKB database and further investigated through PEP-UWM™, PeptideRanker, DBAASP antimicrobial peptide prediction, and ToxinPred tools to identify potential bioactive peptides. Finally, the PepDraw tool was used to obtain the peptide structures of...
Eight peptides (ERFQPMFR, FPVGRGL, PPPVHDFNME, PMAPLPRSGP, LNFDPNR, LAQMEAIR, LPGELAK, and LPQQQAQFK) were selected using the Peptide Ranker program, comparing their amino acid sequences with previous literature. Among them, LNFDPNR and LPQQQAQFK were selected for their high potential...
The aim of the study was to evaluate the potential of rice bran proteins such as glutelin, globulin, and prolamin as a precursor of bioactive peptides using various in silico approaches (BLAST, BIOPEP, PeptideRanker, PepDraw, Pepcalc, and ToxinPred). Rice bran proteins majorly release ...
Many novel peptides without activity reports can be accessed from proteins, and PeptideRanker then exerts its function to evaluate the likelihood of peptide activity by assigning scores from 0 to 1, where “1” and “0” present the most and least likely to be BAPs, respectively [11]. ...
However, it is interesting to mention here that among these 4 peptides, FM had the highest Peptide Ranker score of 1, implying that methionine plays a vital role in determining the bioactivity of peptides (Ibrahim et al., 2018b). Table 2. Potential binding sites between identified bioactive...