PEG conjugation also increases the apparent size of the polypeptide, thus reducing the renal filtration and altering biodistribution. An important aspect of PEGylation is the incorporation of various PEG functional groups that are used to attach the PEG to the peptide or protein. In this paper, ...
1.N any of a group of compounds consisting of two or more amino acids linked by chemical bonding between their respective carboxyl and amino groups 缩氨酸 → see also peptide bond, polypeptide 短语搭配 signal peptide 信号肽 peptide bond [化]肽键 peptide hormone [生化] 肽类激素 ; 肽激素 ; ...
A linear chain of amino acid residues is called a polypeptide. Fig. 3 shows the structures of α-amino acid, the formation of the peptide bond in polypeptide chain and the three-dimensional representation of protein structure. Proteins differ from one another primarily in their sequence of α-...
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Nanopores are single-molecule sensors used in nucleic acid analysis, whereas their applicability towards full protein identification has yet to be demonstrated. Here, we show that an engineered Fragaceatoxin C nanopore is capable of identifying individua
Table 1 Polypeptide and protein used in this research. Full size table After sfGFP-PG4 was successfully secreted in EGPSS, the secretory ability of sfGFP was further tested by fusing with endo-beta-N-acethylglucosamindase H (EndoH, EC3.2.1.96), a monomeric protein with molecular weight of ...
Gene delivery RNA therapeutics Endosomal escape Cell penetrating peptides (CPPs) Protein-based endosomal escape Pore formation Endosomal rupture Phospholipase 1. Introduction 1.1. RNA-based therapies RNA drugs hold immense potential for advancing both biochemical and medical research, particularly in the ...
This is exemplified by the discovery of glucagon-like peptide (GLP)-1 and pancreatic polypeptide hormone (PYY). GLP-1 is a peptide hormone of 30 amino acids, that originates from the proglucagon precursor protein and synthesized in the L cells of the small intestine. GLP-1 regulates both ...
Therapeutic application of peptides and proteins: parenteral forever? Trends Biotechnol 27, 628–635 (2009). Article CAS PubMed Google Scholar Cheloha, R. W., Maeda, A., Dean, T., Gardella, T. J. & Gellman, S. H. Backbone modification of a polypeptide drug alters duration of action...
2. Fusion DNA comprising (1) thioredoxin-like DNA, said thioredoxin-like DNA characterized by encoding a polypeptide that (a) has a three-dimensional structure substantially similar to that of E. coli thioredoxin and (b) contains an active site loop functionally and structurally equivalent to the...