In this technique, previously assembled large-peptide fragments are joined together chemoselectively through the formation of an amide or non-amide linkage.15 This method has the advantage of enforced proximity between the two segments where the local effective concentration of the reactants is hig...
including disulfide linkage information. Structural characterization at this level highlightspost translational modifications(PTMs) such as site-specificglycosylation, amino acid substitutions (sequence variants) and/or truncations which may result from ...
The invention provides activated carboxylic modified polyethylene membranes which comprises a linker coupled by an amide linkage to the surface carboxyl radicals and a method for activating carboxylic acid modified polyethylene membranes, which can be used as supports for C-terminal sequencing of peptides...
A recent extension of this concept is the creation of a covalent linkage between peptide motifs and adaptor domains, which leads to a more stable association of the scaffolded systems and thus bears the potential to further enhance metabolic productivity. 展开 ...
Linkagehelicitymagnetohydrodynamicssolar magnetismThe immune induction by a protein (the tobacco mosaic virus protein — TMVP) was compared to the immune induction by the free, non-conjugated eicosa tryptic peptide fragment of the protein (tryptic......
Selenocysteine (Sec; U) is commonly referred to as the 21st proteinogenic amino acid and is known to be incorporated into at least 25 discrete selenoproteins in humans66. The unique reactivity of the selenol side chain of Sec, namely its low pKaand high oxidation potential and nucleophilicity ...
These findings stand in contrast to mitochondrial leader sequences and the well-studied signal peptides of secretory and certain integral membrane proteins in which no such framework has been observed. 展开 关键词: Linkage helicity magnetohydrodynamics solar magnetism DOI: 10.1002/j.1460-2075.1986.tb04...
An acid-labile anchoring linkage for solid-phase synthesis of C-terminal peptide amides under mild conditions. A series of polymer-supported benzylamides substituted with one to three alkoxy groups in the ring positions were prepared and shown to give carboxamides u... F Albericio,G Barany - 《...
Moreover, the resulting isoindolinimine linkage allows further extension via a one-pot process by reaction with various π electrophiles in high efficiency and selectivity, allowing secondary and even tertiary modification as well as the rapid construction of complex structures. Fig. 1: Stapling of ...
In addition, MD simulation showed that venetoclax binding could also influence the chi angles of M115 and R139 (Fig.3a, Supplementary Fig.7d), in line with the known conformational changes of α3 and α4 helices (Fig.2a). We used a correlation analysis to explore the possible linkage betw...