Since a proportion of the link protein extracted from human and pig cartilage has already undergone proteolysis to remove peptides from its N-terminal region, these peptides may be produced in articular cartilage during the normal process of turnover and ageing. Although a physiological function ...
Proteins and peptides have a great potential as therapeutic agents; they have higher efficiency and lower toxicity, compared to chemical drugs. However, th
Array technology has become a powerful tool for today’s high throughput approaches in biology and chemistry. These large-scale technologies emerged mainly from the genomics field driven by the human genome project and other species sequencing efforts. The associated development of many new technologies...
This journal provides purely theoretical papers and new insight into the principles of protein and peptide structure and function.
Link N peptide (DHLSDNYTLDHDRAIH) is the N-terminal peptide of link protein, which stabilizes the proteoglycan aggregates. It is generated in vivo by proteolytic degradation during tissue turnover. It has been previously shown that this peptide can stimulate the synthesis of collagens by ...
Nanopores are single-molecule sensors used in nucleic acid analysis, whereas their applicability towards full protein identification has yet to be demonstrated. Here, we show that an engineered Fragaceatoxin C nanopore is capable of identifying individua
Post-translational modifications (PTMs) regulate various aspects of protein function, including degradation. Mass spectrometric methods relying on pulsed metabolic labeling are popular to quantify turnover rates on a proteome-wide scale. Such data have traditionally been interpreted in the context of prot...
the selected peptide should be identical to a surface-accessible region (external region, free C- or N-termini, connecting regions), preferably containing a flexible structure or a conformation mimicking the native protein (α-helix, turns, loop). The peptides should be relatively rich in hydroph...
Equine antimicrobial peptides have been detected on mRNA or protein level, respectively, in numerous tissues of the horse (Figure1). Characteristics of the peptides are summarized in table2. The following chapters are introduced by a description of the corresponding peptide family in general. ...
the protein Position-specific scoring matrice (PSSM) and the intrinsic disorder tendency of each residue in both protein and peptide sequences). Each categorical channel contains a self-learning word embedding layer30, which takes one of the categorical features of the input peptide or protein (i...