By chemical linkage to carrier proteins, synthetic peptides carrying target epitopes are able to elicit peptide-specific neutralizing antibodies and potent protection. Peptide vaccine contains no genetic component, so no molecules of pathogens exist in the immunized animals. On the other hand, PV ...
Representative antigens are shown for sphingolipids, polyacylated carbohydrates, lipopeptides, mycolyl lipids, small molecules, diacyl glycerols and polyketides; individual chemical species within each of these general classes can vary with respect to the number, linkage and chemical modifications on ...
Jasplakinolide is a cyclodepsipeptide which represents a new class of antifungal agents with potent activity against Candida albicans. Jasplakinolide is fu... VR Scott,R Boehme,TR Matthews - 《Antimicrobial Agents Chemother》 被引量: 356发表: 1988年 Screening of marine invertebrates for the presence...
we next sought to elucidate the role of secondary HLA class I and class II effects. We similarly considered peptide binding properties and structure of pockets A-F of the class I loci HLA-A, -B and -C and pockets P1, P4, P6,
2–3 h DMSO/H2O O ON P O O– O H NO O NN N O Peptide Peptide-oligonucleotide conjugate (POC) O 40~56% Azidopeptide ON1-BCN ON2-BCN ON3-BCN N3 BCN Click BCN BCN Hybridization Coiled coil Linkage Triplex assembly Figure 1 | Design and assembly of the desired three-helix protein ...
Stapling is a key technique of forcing peptides structure into an α-helical by the linkage of the side chains [335]. A very recent report from Demizu’s group designed and synthesized magainin 2 derivatives by stapling between the first and fifth position from the N-terminus, which showed ...
There is also increasing awareness that alteration of the highly exposed wrapper disulfide bridge linkage pattern can lead to functional switch of scorpion sodium channel toxins via adjusting the conformation of key residues associated with toxin function [84]. In this regard, navitricins with such ...
Lantibiotics are a unique class of peptideantibiotics produced by Gram-positive bacteria. They are highly modified peptides richin lanthionines, a nonproteinogenic aminoacid composes of two alanine residues that arecrosslinked on theirβ-carbon atoms by a thioether linkage, combining the beneficial bi...
Gene therapy is the ultimate therapeutic technology for diseases related to gene abnormality. However, the use of DNA alone has serious problems, such as poor stability and difficulty in entering target cells. The development of a safe and efficient gene
As a result of competitive conjugation, the rotation barriers of substituted ureas are lower than those of its corresponding native amides, and one might expect greater flexibility of the urea linkage in solution. Accordingly, we found that the urea moiety in simple N-acyl-N-carbamoyl-gem-...