This study aimed to evaluate disparities in enrollment on pediatric oncology clinical trials. We assessed the relationship between patient characteristics and enrollment on COG trial AAML1031 in a cohort of pediatric patients with AML in the Pediatric Health Information System. The associations of ...
The FDA has granted a rare pediatric disease designation to GPS for the treatment of pediatric patients with AML.1 "GPS has already demonstrated promise in clinical settings for AML, and we believe its potential could extend to pediatric patients,” said Angelos Stergiou, MD, ScD hc, preside...
FDA Puts Hold on Phase 1 SC-DARIC33 Trial in Pediatric R/R AML Russ Conroy August 19th 2023 Investigators will work with the FDA to assess the root cause of a grade 5 serious adverse effect in phase 2 PLAT-08 trial evaluating SC-DARIC33 in pediatric acute myeloid leukemia. ...
which collects "valuable real-world treatment and response data, as well as comprehensive molecular characterization," for children with relapsed and refractory AML who are not enrolled in clinical trials. This
We conducted a cytogenetic analysis of 642 children with de novo acute myeloid leukemia (AML) treated on the AML-Berlin-Frankfurt-Münster (BFM) 04 protocol to determine the prognostic value of specific chromosomal aberrations including monosomal (MK+),
On the other hand, acute myeloid leukemia (AML) is cancer of the blood in which too many myeloblasts, immature white blood cells, are produced in the bone marrow. Chronic leukemia’s are rare in children. Chronic myeloid leukemia (CML) and chronic lymphocytic leukemia (CLL). Related ...
Little is known about the impact of enrollment on therapeutic clinical trials on adverse event rates. Primary objective was to describe the impact of clinical trial registration on sterile site microbiologically documented infection for children with newly diagnosed acute myeloid leukemia (AML). We ...
Pediatric low-grade glioma: Targeted therapeutics and clinical trials in the molecular era.Neoplasia. 2023 Feb;36:100857. doi:10.1016/j.neo.2022.1008572. Wright KD, Yao X, London WB, et al. A POETIC Phase II study ofcontinuous oral everolimus in recurrent, radiographically progressive pediat...
Acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) are the 2 most common types of childhood leukemia. Each year in the US, about 3000 children and adolescents are diagnosed with ALL and about 700 are diagnosed with AML. How Is Childhood Leukemia Diagnosed? To diagnose childhood...
Disparities in pediatric acute myeloid leukemia (AML) clinical trial enrollment. Leuk Lymphoma. 2019;60:2190–8. Article PubMed PubMed Central Google Scholar Bleyer A. The adolescent and young adult gap in cancer care and outcome. Curr Probl Pediatr Adolesc Health Care. 2005;35:182–217. ...