We identified a 69 lncRNA signature AML lnc69 that is highly predictive of relapse risk (c-index= 0.73), with area under the receiver operating characteristic curve (AUC) values for predicting the 1-, 2-, and 3-year relapse-free survival (RFS) of 0.78, 0.77, and 0.77, respectively. ...
Prognosis of acute myeloid leukemia (AML) patients depends on patient-related features, disease manifestations at the time of presentation, and intrinsic disease-related genetic features, such as cytogenetic abnormalities and driver mutations. Prognostic
However, the majority of AML pa- tients are older than the previously studied patients [5], and clinical prognostic factors such as age and perform- ance status (PS) were not examined in the previous stud- ies, nor are these factors included in the ELN-2017 guidelines [1, 6–8]. ...
Herein, we report the single-center experience with a modified BFM-90 protocol, a pediatrics-inspired regimen, in AYA ALL patients aged 15 to 25 years. We aimed to evaluate the efficacy and safety and identify the impact of prognostic factors (minimal residual disease [MRD], baseline white bl...
EVI1 and MEL1 are homolog genes whose transcriptional activations by chromosomal translocations are known in small subsets of leukemia. From gene expression profiling data of 130 Japanese pediatric acute myeloid leukemia (AML) patients, we found that EVI1 and MEL1 were overexpressed in ~30% of pa...
factors, a nomogram was constructed using the rms package [22]. The nomogram's predictive accuracy was evaluated using a calibration curve. To explore gene expression differences between high- and low-risk groups in the TARGET-cALL-P2 dataset, differential expression analysis was performed using ...
mutations in various genes, such as FLT3, IDH2, NPM1, WT1, and CEBPA, and, more recently, TP53 have been recognized as factors for risk stratification. Alterations in the expression patterns of specific genes have also been identified as crucial in the diagnosis and treatment of AML [16,17...
The univariable and multivariable Cox regression analyses showed that both age and risk score were significantly associated with the OS of AML patients and served as independent prognostic factors (Fig.4A, B). The AUC values of the 1-, 3-, and 5-year survival were 0.846, 0.801, and 0.895,...
Acute myeloid leukemia (AML) is a hematopoietic disorder initiated by the leukemogenic transformation of myeloid cells into leukemia stem cells (LSCs). Preexisting gene expression programs in LSCs can be used to assess their transcriptional similarity to hematopoietic cell types. While this relationship...
Class II mutations, such as PML/RARA, CBFB/MYH11, RUNX1/RUNX1T1, MLL/PTD, CEBPA, and SPI1 mutations, inactivate transcriptional factors or cofactors resulting in impaired hematopoietic differentiation. Among these, FLT3/ITD and MLL/PTD are associated with inferior overall and relapse-free ...