The results suggest that as long as trough concentrations do not exceed 15 mg/L, peak levels will not exceed normally accepted safe concentrations, and therefore do not need to be measured.N.JSaundersSDOSLancetSaunders NJ. Why monitor peak vancomycin concentrations? Lancet. 1994;344:1748–50. ...
Approaches to vancomycin TDM vary, with no head-to-head randomized controlled trial (RCT) comparisons to date. We aimed to compare clinical and pharmacokinetic outcomes between peak-trough-based and trough-only-based vancomycin TDM approaches and to determine the relationship between vancomycin AUC 24...
Vancomycin (VCM) is a glycopeptide antibiotic that was developed and used in the 1950s to treat aerobic Gram-positive infections, and is currently used...
Multivariate analysis was used to adjust for significant factors with p < 0.05 and identify new factors affecting the achievement of the target AUC at steady-state for VCM. Among the 113 patients included in this study, 72 (64%) were in the 1-point group (trough only)...
Approaches to vancomycin TDM vary, with no head-to-head randomized controlled trial (RCT) comparisons to date. We aimed to compare clinical and pharmacokinetic outcomes between peak–trough-based and trough-only-based vancomycin TDM approaches and to determine the relationship between vancomycin AUC24...
Objective: To compare trough and peak serum gentamicin concentrations in neonatal patients using two dosing regimens. Method: A retrospective audit of ... N Gooding,A Elias-Jones,M Shenoy - 《Pharmacy World & Science Pws》 被引量: 30发表: 2001年 Prediction of gentamicin peak and trough concent...
Because the association between vancomycin peak concentrations and toxicity is poor, some have recommended measuring trough concentration only4 as this study is clearly documenting, but others have suggested not measuring any concentrations in the majority of children with normal renal function.5 However,...
Adult non-dialysis patients initiated on vancomycin were randomized to peak-trough-based or trough-only-based vancomycin TDM. Primary endpoints included vancomycin AUC 24 /MIC ratio breakpoint for cure and clinical effectiveness (therapeutic cure vs therapeutic failure). Descriptive, inferential, and ...
VancomycinInternational Journal of Clinical Pharmacy - Vancomycin area under the curve/minimum inhibitory concentration (AUC/MIC) has been proposed as a therapeutic drug monitoring (TDM) target to dose...doi:10.1007/s11096-022-01474-9Wang, Liming...
Why monitor peak vancomycin concentrations? Lancet. 1994;344:1748-1750.MacGowan, A., Lovering, A., White, L. & Reeves, D. (1995). Why monitor peak vancomycin concentrations? Lancet 345, 645.Wysocki M, Thomas F, Wolff M. Why monitor peak vancomycin concentrations? Lancet 1995;345:646....