Peak concentrations of 20-40 mg/l were found in 83.2% of infants, and 15-60 mg/l in 99.0%. Highest peak concentration was 47.2 mg/l. Some 89.4% of infants with trough concentrations of 5-10 mg/l had a peak concentration of 20-40 mg/l.The vancomycin dosage regimen used in this ...
Vancomycin (VCM) is a glycopeptide antibiotic that was developed and used in the 1950s to treat aerobic Gram-positive infections, and is currently used...
Infants who had been started on vancomycin before they were transferred to the unit were excluded. The proportion of infants was measured whose serum vancomycin concentrations were within a conservative therapeutic range of trough 5–10 mg/l, peak 20–40 mg/l, and a less conservative, but ...
The results suggest that as long as trough concentrations do not exceed 15 mg/L, peak levels will not exceed normally accepted safe concentrations, and therefore do not need to be measured.N.JSaundersSDOSLancetSaunders NJ: Why monitor peak vancomycin concentrations? Lancet 1994; 344:1748-50...
vancomycinThe therapeutic drug monitoring (TDM) of vancomycin (VCM) in critically ill patients often results in the estimated area being under the concentration-time curve (AUC) values that deviate from individual observations. In this study, we investigated the factors influencing the achievement of ...
VancomycinInternational Journal of Clinical Pharmacy - Vancomycin area under the curve/minimum inhibitory concentration (AUC/MIC) has been proposed as a therapeutic drug monitoring (TDM) target to dose...doi:10.1007/s11096-022-01474-9Wang, Liming...
Multivariate analysis was used to adjust for significant factors with p < 0.05 and identify new factors affecting the achievement of the target AUC at steady-state for VCM. Among the 113 patients included in this study, 72 (64%) were in the 1-point group (trough only)...
We aimed to compare clinical and pharmacokinetic outcomes between peak–trough-based and trough-only-based vancomycin TDM approaches and to determine the relationship between vancomycin AUC24/MIC and cure rates. A multicentered pragmatic parallel-group RCT was conducted in...
Because the association between vancomycin peak concentrations and toxicity is poor, some have recommended measuring trough concentration only4 as this study is clearly documenting, but others have suggested not measuring any concentrations in the majority of children with normal renal function.5 However,...