Plots seasonal variation, trend and linear predictor obtained from or PeakTrough 被引量: 0发表: 0年 Evaluation of High Trough-to-Peak Ratio of Perindopril in Shr The present study was designed to evaluate trough-to-peak ratio (T/P) of ACE inhibitors in spontaneously hypertensive rats (SHR) ...
peaks and troughs→ auges mpl y depresiones fplsee also widow B B. VI [temperatures]→ alcanzar su punto más alto; [inflation, sales]→ alcanzar su nivel máximo; [crisis]→ alcanzar su momento crítico; [career]→ alcanzar su cumbre or su cúspide; [sportsperson]→ alcanzar su mejor...
In addition, the book Neofax: a Manual of Drugs Used in the Neonatal Care by Young and Mangum [2007] was consulted. Results: The peak and trough concentrations were compared after the following dosing schedules of gentamicin 2.5 mg/kg twice-daily dosing, 4 mg/kg once-daily dosing and 5 ...
Trough/peak ratios for antihypertensive agents. The issues in perspective. In 1988, the Cardiovascular and Renal Drugs Advisory Committee of the US Food and Drug Administration (FDA) met in the company of leading experts to consid... P Meredith - 《Drugs》...
Demographic data, donor type, current immuno-suppressant regimen, concurrent medical problems, and concurrent drugs were obtained. Variability of C2 and Co monitoring was assessed from the coefficient of variation (CV) of dose-adjusted peak and trough levels, respectively. The effects of dosage ...
Background: One of the important characteristic features of the new antihypertensives drugs is its 24-hour effectiveness. If the drug reaches the mean trough/peak over 50% it can be dosed once daily. The pulse pressure (PP) increases with the age and correlates better with the organs damage...
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Medical Dictionary for the Health Professions and Nursing © Farlex 2012 peak (pēk) The top or upper limit of a graphic tracing or of any variable. [M.E.peke,pike, fr. Sp.pico, beak, fr. L.picus, magpie] Medical Dictionary for the Dental Professions © Farlex 2012 ...
Rights and permissions Reprints and permissions About this article Cite this article Millar, J. Shortcomings in the trough to peak ratio as a guide to the dose interval for antihypertensive drugs. J Hum Hypertens 12, 37–44 (1998). https://doi.org/10.1038/sj.jhh.1000537 Download citation Rec...
Intuitively, drugs that have a low trough-to-peak ratio should be associated with an increased blood pressure load as the agent is losing its effectiveness at the end of the dosing period. However, the extent of the reduction at trough and peak times must be taken into consideration when eva...