Therefore, PD1 or PDL1 inhibitors do not seem to be suitable treatment options for immunotherapy in most patients with Mantle cell lymphoma. It seems that age may have a negative effect on the effectiveness of checkpoint inhibitor therapy. This finding may also explain the increase in the risk ...
The effects of inhibitors of three signaling pathways on P62. (A) Correlation between JAK2/STAT3 and P62 in TCGA. (B) Western blotting showing the effect of pSTAT3 inhibitor Stattic (12 h) on P62 in T24 cells. (C) Correlation between AKT/MTOR and P62 in TCGA. (D) Western blotting sho...
This study identified genetic networks containing major immune-checkpoint inhibitors CD27, PD1, and PDL1, and their associated prognostic genes and proliferation genes in lung cancer tumors. A 5-gene prognostic model was developed and validated in extensive cohorts to select patients at a high risk...
1 Zhou CC, Wang J, Bu H, et al. Chinese experts consensus on immune checkpoint inhibitors for non-small cell lung cancer (2019 version). Zhongguo Fei Ai Za Zhi, 2020, 23(2): 65-76. [周彩存, 王洁, 步宏, 等. 中国非小细胞肺癌免疫检查点抑制剂治疗专家共识(2019年版). 中国肺癌杂志, ...