These findings suggest a direct role of CDK7-dependent PD-L1 expression in mediat- ing antiPD-1 therapy sensitivity. More importantly, there were no significant increased treatment-related toxicities in the combined therapies. However, the optimal drug doses and se- quences in the combined ...
Programmed cell death 1 ligand 1, PD-L1, PDCD1 ligand 1, Programmed death ligand 1, B7 homolog 1, B7-H1, CD274, Cd274, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1 Concentration 1.86 mg/ml Endotoxin level Please contact with the lab for this information. Purity >95% as determined by SDS-PA...
PD-L1 degradation and how NSCLC immune escape through KEAP1-PD-L1 signaling. Our results also suggest that KEAP1 agonist might be a potential clinical drug to boost anti-tumor immunity and improve immunotherapies in NSCLC. Similar content being viewed by others YTH domain family protein 3 acceler...
PD-L1 expression is the most useful predictive biomarker for immunotherapy efficacy on non-small cell lung cancer (NSCLC), and CD8+ tumor-infiltrating lymphocytes (CD8+ TILs) play an essential role in the clinical activity of immunotherapy. PD-L1 i
At present, the biology that governs response to anti-PD-1 monotherapy compared with combined anti-CTLA-4 and anti-PD-1 immunotherapy is largely unknown. The only Food and Drug Administration-approved companion diagnostics are PD-L1 immunohistochemical assays; however, this is only applicable in th...
YIV-906 (PHY906) is a standardized botanical cancer drug candidate developed with a systems biology approach—inspired by a traditional Chinese herbal formulation, historically used to treat gastrointestinal symptoms including diarrhea, nausea and vomiting. In combination with chemotherapy and/or radiation...
with PD-1/PD-L1 blockers and the drugs were ranked based on their mechanism of action and known clinical efficacy. Nineteen drugs or drug classes were identified from an internal list of lead molecules and were scored for their clinical potential. Efficacy and safety data from pivotal studies ...
For example, we showed that drug-resistant malignant cells (e.g. lung cancer cells) are more sensitive to pharmacological doses of selenite compared to normal cells [8,20]. The suggested mechanism includes targeting the resistant phenotype comprising increased levels of thiols, induction of redox-...
et al., “Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired,” Blood. Aug. 20, 2009;114(8):1537-1544. doi: 10.1182/blood-2008-12-195792. Epub May 7, 2009. Amarnath, et al., “The PDL1-PD1 Axis Converts Human ...
Provided herein are antibodies, and antigen-binding fragments thereof that specifically bind glucocorticoid-induced tumor necrosis factor receptor (GITR) and methods of using the sa