YIV-906 (PHY906) is a standardized botanical cancer drug candidate developed with a systems biology approach—inspired by a traditional Chinese herbal formulation, historically used to treat gastrointestinal symptoms including diarrhea, nausea and vomiting. In combination with chemotherapy and/or radiation...
At present, the biology that governs response to anti-PD-1 monotherapy compared with combined anti-CTLA-4 and anti-PD-1 immunotherapy is largely unknown. The only Food and Drug Administration-approved companion diagnostics are PD-L1 immunohistochemical assays; however, this is only applicable in th...
with PD-1/PD-L1 blockers and the drugs were ranked based on their mechanism of action and known clinical efficacy. Nineteen drugs or drug classes were identified from an internal list of lead molecules and were scored for their clinical potential. Efficacy and safety data from pivotal studies ...
PD-L1 expression is the most useful predictive biomarker for immunotherapy efficacy on non-small cell lung cancer (NSCLC), and CD8+ tumor-infiltrating lymphocytes (CD8+ TILs) play an essential role in the clinical activity of immunotherapy. PD-L1 i
in U.S. ImmuneOncia leverages both companies’ expertise in drug development and antibody engineering. The company’s mission is to bring safe, effective, and novel immunotherapies to oncology patients world-wide, and its diverse immune checkpoint inhibitor portfolio...
These findings suggest a direct role of CDK7-dependent PD-L1 expression in mediat- ing antiPD-1 therapy sensitivity. More importantly, there were no significant increased treatment-related toxicities in the combined therapies. However, the optimal drug doses and se- quences in the combined ...
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Nevertheless, depletion of CD8 T-cells from mice bearing PDL1-deficient tumours completely abrogated tumour regressions (Fig. 2j), indicating that despite qualitative changes to the immune and stromal environment, the increased T-effector phenotype remained the main driver behind tumour rejections and ...
PD-L1 degradation and how NSCLC immune escape through KEAP1-PD-L1 signaling. Our results also suggest that KEAP1 agonist might be a potential clinical drug to boost anti-tumor immunity and improve immunotherapies in NSCLC. Similar content being viewed by others...
et al., “Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired,” Blood. Aug. 20, 2009;114(8):1537-1544. doi: 10.1182/blood-2008-12-195792. Epub May 7, 2009. Amarnath, et al., “The PDL1-PD1 Axis Converts Human ...