(OPCs) [4,5]. Conditional ablation ofPdgfrain mouse accelerates OPC differentiation and thus causes dysmyelination due to the reduced number of OPCs, mimicking the phenotypes ofPdgfa-null mice [6,7]. However, besides OPCs, PDGFRA was also expressed in a subpopulation of basal multipotent ...
(OPCs) based on the expression of CD140a (PDGFRα). The isolation was tested particularly on dissociated postnatal CD1 mouse brain tissue derived from animals younger than postnatal day eight (P8). In principle, cell isolation is also possible from older mice, but purity of the positive ...
Conditional ablation of Pdgfra in mouse accelerates OPC differentiation and thus causes dysmyelination due to the reduced number of OPCs, mimicking the phenotypes of Pdgfa-null mice [6,7]. However, besides OPCs, PDGFRA was also expressed in a subpopulation of basal multipotent intermediate ...