The CD140a (PDGFRα) MicroBead Kit was developed for the direct isolation or depletion of CD140a (PDGFRα) positive oligodendrocyte precursors from dissociated mouse brain tissue. | Miltenyi Biotec | 中国
Myxoid glioneuronal tumors (MGNT) are low-grade glioneuronal neoplasms composed of oligodendrocyte-like cells in a mucin-rich stroma. These tumors feature a unique dinucleotide change at codon 385 in the platelet-derived growth factor receptor 伪 (encoded by the PDGFRA gene), resulting in the ...
[1-3]. In the developing rodent CNS, PDGFRa specifically marks the oligodendrocyte progenitor cells (OPCs) [4,5]. Conditional ablation ofPdgfrain mouse accelerates OPC differentiation and thus causes dysmyelination due to the reduced number of OPCs, mimicking the phenotypes ofPdgfa-null mice [...
In the developing rodent CNS, PDGFRa specifically marks the oligodendrocyte progenitor cells (OPCs) [4,5]. Conditional ablation of Pdgfra in mouse accelerates OPC differentiation and thus causes dysmyelination due to the reduced number of OPCs, mimicking the phenotypes of Pdgfa-null mice [6,7]...
H3K27M-mutated diffuse midline glioma (H3K27M DMG) are an almost universally fatal disease with a median survival of less than 6 months post progression and no effective therapy. PDGFRA-signaling has shown to promote and sustain a subset of oligodendrocyte precursor-like tumor cells that are ...
In the brain of this reporter mouse, the majority of cells expressing GFP are of the oligodendrocyte lineage. However, there is a small subset of cells that are not belonging to this lineage, and present an interesting anatomical location. They are localized in close proximity to the larger ...