PDGFRα与PDGFRβ的结构 PDGFRα和PDGFRβ均包含和配体结合的胞外结构域（D1-D5）、将胞外信号传到胞内的单次跨膜结构域（transmembrane helix，TM）、胞内近膜段（juxtamembrane segment，JM）、激酶域（kinase domain，包括kinase domain 1 (KD1)、kinase insert (KI)、kinase domain 2 (KD2)）和C末端酸性尾...
PDGFRα和PDGFRβ均包含和配体结合的胞外结构域(D1-D5)、将胞外信号传到胞内的单次跨膜结构域(transmembrane helix,TM)、胞内近膜段(juxtamembrane segment,JM)、激酶域(kinase domain,包括kinase domain 1 (KD1)、kinase insert (KI)、kinase domain 2 (KD2))和C末端酸性尾巴(Tail)。胞外域含多个糖基化位...
PDGFRα和PDGFRβ均包含和配体结合的胞外结构域(D1-D5)、将胞外信号传到胞内的单次跨膜结构域(transmembrane helix,TM)、胞内近膜段(juxtamembrane segment,JM)、激酶域(kinase domain,包括kinase domain 1 (KD1)、kinase insert (KI)、kinase domain 2 (KD2))和C末端酸性尾巴(Tail)。胞外域含多个糖基化...
We first detected alterations in PDGFR-β levels in the subchondral bone of humans with OA. Western blot results showed that the PDGFR-β level was remarkably elevated in the osteoarthritic part of the human subchondral bone compared with the relatively normal (RN) part (Fig.1a, b).7This ele...
目的:通过检测胃肠道间质瘤中血小板衍生生长因子受体 -α(PDGFR-α)的表达情况,探讨PDGFR-α在胃肠道间质瘤中的诊断及预后意义.方法:应用免疫组织化学EnvisionTM二步... 郑松,陈丽荣,王海军,... - 《浙江大学学报(医学版)》 被引量: 19发表: 2007年 C-kit和PDGFR ...
PDGFR beta/CD140b Uni-rAbTM Recombinant Antibody for WB, IHC, Indirect ELISAHost / Isotype Rabbit / IgG Reactivity human Applications WB, IHC, Indirect ELISA Conjugate Unconjugated CloneNo. 230214D11Cat no : 82943-1-PBS Synonyms PDGFRB, EC:2.7.10.1, CD140B, CD140 antigen-like family...
Here, we find that also PDGFRβ-TM has a propensity to dimerize by itself, which adds a further example to the above mentioned group of RTKs. We have combined a high resolution NMR structure analysis in dodecylphosphocholine (DPC) micelles with a study on the orientation of the TM dimer ...
首先,我们利用Nkx2.5cre/+;R26Rm Tm G的转基因小鼠对心脏祖细胞及其衍生细胞中Pdgfrα表达进行追踪,结果显示:在小鼠胚胎心脏早期发育过程中,心脏祖细胞均强烈表达PDGFRα.利用c Tn T抗体,α-SMA抗体和CD31抗体,通过免疫荧光技术对小鼠胚胎冰冻切片进行免疫荧光染色,对该小鼠胚胎心脏中NKX2.5+和PDGFRα+细胞的细胞类型...
C—kit和PDGFR—β在硬纤维瘤中的表达及意义
TM and DCW maintained the patient database. KC, LV, DCW, and SG provided statistical analysis. TPWM, ALC, LV, and DB wrote the paper with input from all authors. TPWM, DCW and ALC are inventors on the patent describing PDGFRα blockade to restore radioactive iodine sensitivity. ...