PDGFRα与PDGFRβ的结构 PDGFRα和PDGFRβ均包含和配体结合的胞外结构域（D1-D5）、将胞外信号传到胞内的单次跨膜结构域（transmembrane helix，TM）、胞内近膜段（juxtamembrane segment，JM）、激酶域（kinase domain，包括kinase domain 1 (KD1)、kinase insert (KI)、kinase domain 2 (KD2)）和C末端酸性尾...
PDGFRα与PDGFRβ的结构 PDGFRα和PDGFRβ均包含和配体结合的胞外结构域(D1-D5)、将胞外信号传到胞内的单次跨膜结构域(transmembrane helix,TM)、胞内近膜段(juxtamembrane segment,JM)、激酶域(kinase domain,包括kinase domain 1 (KD1)、kinase insert (KI)、kinase domain 2 (KD2))和C末端酸性尾巴(Tail)...
PDGFRα和PDGFRβ均包含和配体结合的胞外结构域(D1-D5)、将胞外信号传到胞内的单次跨膜结构域(transmembrane helix,TM)、胞内近膜段(juxtamembrane segment,JM)、激酶域(kinase domain,包括kinase domain 1 (KD1)、kinase insert (KI)、kinase domain 2 (KD2))和C末端酸性尾巴(Tail)。胞外域含多个糖基化...
subchondral H Talin, a 270 kD dimeric adaptor protein, is composed of a C-terminal flexible rod field and an N-terminal globular head domain that can be detached by calpain 2 cleavage.32The N-terminal head of talin harbors an analogous FERM domain that comprises several binding sites for ...
von Bubnoff N, Gorantla SP, Engh RA, Oliveira TM, Tho篓 ne S, Aberg E et al. The low frequency of clinical resistance to PDGFR inhibitors in myeloid neoplasms with abnormalities of PDGFRA might be related to the limited repertoire of possible PDGFRA kinase domain mutations in vitro. ...
After washing with PBS, the retina and RCS complexes were mounted with FluoromountTM Aqueous Mounting Medium (#F4680, Sigma-Aldrich, St. Quentin, France) and observed under a confocal microscope (Leica TCS STED; Leica Microsystems Ltd., Wetzlar, Germany). Induction of oxygen-induced retinopathy ...
HMG-box domain containing 3 HSC: Hematopoietic stem cells Ifi20: Interferon-inducible P204 protein IFNγ: Interferon γ Ig: Immunoglobulin IL-3: Interleukin-3 IL-34: Interleukin-34 IL-4: Interleukin-4 IPC: Type 1 interferon-producing cells IRSp53: Insulin receptor tyrosine kinase ...
Inserting disulfide bridges at various positions of the TM domain (8), replacing the native TM against the TM of the constitutively active oncogenic form of the NEU receptor (9, 10), or using a simplified TM motif consisting of a stretch of valines with one or two glutamates (11), have...
PDGFRα和PDGFRβ均包含和配体结合的胞外结构域(D1-D5)、将胞外信号传到胞内的单次跨膜结构域(transmembrane helix,TM)、胞内近膜段(juxtamembrane segment,JM)、激酶域(kinase domain,包括kinase domain 1 (KD1)、kinase insert (KI)、kinase domain 2 (KD2))和C末端酸性尾巴(Tail)。胞外域含多个糖基化位...
In silico analysis identified TEA domain transcription factor 4 (TEAD4) as a candidate transcriptional regulatory element of KRT19 (Supplementary Table S2 and Supplementary Figure S3). Upon Ln-111 coating, TEAD4 shifted from the cytoplasm to the nucleus, suggesting transcriptional activity (...