在内体中,PDGFRA介导的TGFB1/SMAD信号激活后促进了GMCs分化为肌成纤维细胞、细胞外基质沉积和血管纤维化。这些反应导致新生内膜形成和AVF失败。敲除PDGFRA或者抑制GMCs中的HH信号可阻抑GMC向肌成纤维细胞的分化。体内实验发现,特异性敲除Pdgfra可抑制GMC活化和血管纤维化,抑制新内膜形成并最终改善CKD情况下的AVF开放情况。
Therefore, PDGFRA might be not necessary for PDGFA function.To profile proteins involved in PDGFA function, we performed co-immunoprecipitation (Co-IP) and Mass Spectrum (MS) and delineated the network of PDGFA-associated proteins for the first time. Unexpectedly, the data showed that EPHA2 ...
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PDGFRA PDGFRA/BCR fusion PDGFRB PDGFRB PDGFRL PDGG PDGI PDGMS PDGN PDGO PDGP PDGPC PDGS ▼Complete English Grammar Rules is now available in paperback and eBook formats. Make it yours today! Advertisement. Bad banner? Please let us know Remove AdsFace...
MiR-146a enhances angiogenic activity of endothelial cells in hepatocellular carcinoma by promoting PDGFRA expression. Carcinogenesis, 34 (9) (2013), pp. 2071-2079 Google Scholar 40 JM Goldman, JV Melo Chronic myeloid leukemia–advances in biology and new approaches to treatment. N Engl J Med, ...
Platelet-derived growth subunit A(PDGFA)plays critical roles in development of glioblastoma(GBM)with substantial evidence from TCGA database analyses and in vivo mouse models.So far,only platelet-derived growth receptor a(PDGFRA)has been identified as receptor for PDGFA.However,PDGFA and PDGFRA ...
Molecular Alterations of PDGFA and PDGFRA in GliomasTimes Cited: 0O. MartinhoA. Longatto-FilhoM. B. K. LambrosA. MartinsR. M. ReisModern Pathology
The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. It also interacts with CSPG4. The long form contains a basic insert which acts as a cell retention signal.Source: Entrez Gene; Swiss-ProtCatalog Number KA...
Conditional knockout of the Pdgfra gene in the myocardium does not lead to any visible anatomic defects. All these lead to the search for additional factors. An expression microarray study of MEC1 cells suggested Igf2 as another candidate trophic factor. In situ hybridization showed that Igf2 ...