9、Wu T, Zhang X, Liu X, et al. Single-cell sequencing reveals the immune microenvironment landscape related to anti-PD-1 resistance in metastatic colorectal cancer with high microsatellite instability. BMC medicine. 2023 Apr 27;21(1):161. ...
7、Zou, R., Wang, Y., Ye, F. et al. Mechanisms of primary and acquired resistance to PD-1/PD-L1 blockade and the emerging role of gut microbiome. Clin Transl Oncol23, 2237–2252 (2021). https://doi.org/10.1007/s12094-021-02637-2 8、Fillon M. Fecal microbiota transplants may ...
原发性耐药(primary resistance):是指PD-1抑制剂用上去肿瘤压根就没反应;也就是所谓的“冷肿瘤”。这也正好解释了PD-1/PD-L1单抗单药二线的有效率在20%左右,大部分肿瘤患者接受免疫治疗后并不会出现临床获益这个现象。 获得性耐药(acquired resistance),是指曾经用PD-1抑制剂起效过但是时间长了以后,肿瘤开始复发...
2022年2月23日,复旦大学樊嘉,柯爱武及蔡加彬共同通讯在Journal of Hepatology在线发表题为“PKCα/ZFP64/CSF1 axis resets the tumor microenvironment and fuels anti-PD1 resistance in hepatocellular carcinoma”的研究论文,该研究发现锌指蛋...
2022年2月23日,复旦大学樊嘉,柯爱武及蔡加彬共同通讯在Journal of Hepatology在线发表题为“PKC%u3B1/ZFP64/CSF1 axis resets the tumor microenvironment and fuels anti-PD1 resistance in hepatocellular carcinoma”的研究论文,该研究发现锌指蛋白 64 (ZFP64) 在抗 PD1 耐药 HCC 患者的肿瘤组织中经常上调。升高...
Resistance to PD1/PDL1 checkpoint inhibition. Cancer Treat Rev. 2017;52:71-81.O'Donnell JS, Long GV, Scolyer RA, Teng MW, Smyth MJ. Resistance to PD1/PDL1 checkpoint inhibition. Cancer Treat Rev. 2017; 52:71-81.O'Donnell JS, Long GV, Scolyer RA, Teng MW, Smyth MJ. Resis- ...
Here, with the aim of guiding future combination trials that target specific resistance mechanisms to immunotherapies, we have summarised and discussed the current understanding of mechanisms promoting resistance to anti-PD1/PDL1 therapies, and how combination strategies which target these pathways might ...
近期发表在Front. Cell Dev. Biol的发表在“Resistance Mechanisms of Anti-PD1/PDL1 Therapy in Solid Tumors”很好的总结了目前关于PD1 / PDL1治疗的原发性和获得性耐药可能的机制以及改善PD1 / PDL1治疗耐药性的策略的进展。 1. 原发性耐药 在PD1/PDL1治疗中,肿瘤可以通过形成肿瘤微环境(TME)来阻碍T细胞的...
However, anti-PD1 resistance precludes such benefits in many cases. Here we attempted to overcome anti-PD1 resistance by combining localized radiation with a radioenhancing nanoparticle (NBTXR3) and systemic anti-PD1 treatment to achieve abscopal effects in an anti-PD1-resistant mouse model of ...
Cancer cell-derived exosomal circUSP7 induces CD8+ T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC 02关键词 circUSP7, 非小细胞肺癌, 外泌体, Anti-PD1, miR-934, SHP2 03全部作者 Shi‑Wei Chen, Shu‑Qiang Zhu, Xu Pei†, Bai‑Quan Qiu, Dian...