2025年3月19日,武汉大学人民医院马振国团队在Nature Communications上在线发表题为“Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in mice”的研究论文。研究报道了...
[10] MANFREDO VIEIRA S, HILTENSPERGER M. KUMAR V, et al Translocation of a gut pathobiont drives autoimmunity in mice and humans J. Science,2018.39(6380:1156-1161. 上下滑动查看更多图片 收录于合集#肠菌移植 4个
[2] PD1 makes waves in anticancer immunotherapy. Nat Rev Drug Discov. 2012, 11(8):601. [3] Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia. Blood. 2011,117(17):4501-10....
Moreover, Pd1cKO mice exhibit depressive-like behaviors, including immobility, despair, and anhedonia. Mechanistically, Pd1 regulates embryonic neurogenesis by targeting Pax3 through the 尾-catenin signaling pathway. The constitutive expression of Pax3 partly rescues the deficiency of neurogenesis in the ...
[15] Burova E, et al. Characterization of the Anti-PD-1 Antibody REGN2810 and Its Antitumor Activity in Human PD-1 Knock-In Mice. Mol Cancer Ther;16(5) May 2017. [16] Zhang S, et al. Antibody Therapeutics, 2018, Vol.1, No. 2:45-53 ...
2024年5月,香港中文大学于君团队在《Nature Microbiology》杂志上发表了一篇题为“Peptostreptococcus anaerobius mediates anti-PD1 therapy resistance and exacerbates colorectal cancer via myeloid-derived suppressor cells in mice”的论文。该研究探讨了口腔微生物厌氧消化链球菌(Peptostreptococcus anaerobius)在结直肠癌...
2023年8月8日,中国科学院动物研究所焦建伟课题组与首都医科大学宣武医院菅凤增课题组和中山大学肿瘤防治中心谢敬敦课题组合作在CellDeathandDifferentiation上发表题为“Brain-specific Pd1 Deficiency Leads to Cortical Neurogenesis Defects and Depressive-like Behaviors in Mice”的研究论文,从新的角度揭示了PD1在早期脑...
I are responsible for dilated cardiomyopathy in PD-1-deficient mice[J]. Nat Med,2003,9( 12) : 1477-1483. [19] 杨浩,彭瑛,李娅姣,等.程序性细胞死亡因子1基因单核苷酸多态性与中国扩张型心肌病的相关性研究[J].中华医学遗传学杂志,2014,31( 3) : 362- 366. [20] Grabie N,Gotsman I,Dacosta...
Using both overexpression of PDL1 and blocking antibodies against PDL1, the authors show that perturbing the PD1 pathway can influence tumour growth in mice. CAS PubMed PubMed Central Google Scholar Iwai, Y., Terawaki, S. & Honjo, T. PD-1 blockade inhibits hematogenous spread of poorly ...
PD1 reduces T cell receptor activity via SHP2-dependent dephosphorylation of multiple pathways; accordingly, inhibiting PD1 activity through monoclonal antibodies increases CD8+ T cell effector response in young mice8,9,10,11. Attempts to improve CD8+ T cell responses by blocking inhibitory receptors ...