H. Cen, Q. Ke, Z. Li, et al. shRNA-mediated PD1 gene knock-down anti-CD19 CAR-T cell therapy for relapsed/refractory b cell malignancies. 2022ESMO. Abstract 619O. 来源:梅斯医学 授权转载,投稿及爆料请及时联络...
Haplotype analysis of human AMPD1 gene: origin of common mutant allele. J Med Genet 2004;41(6):e74.Toyama K, Morisaki H, Kitamura Y, Gross M, et al. (2004). Haplotype analysis of human AMPD1 gene: origin of common mutant allele. J. Med. Genet. 41: e74. http://dx.doi.org/...
Previous studies showed an association of the common functional polymorphism (C34T, Gln12Stop) in the adenosine monophosphate deaminase-1 (AMPD1) gene with survival in heart failure (HF) and/or coronary artery disease (CAD). The aim of the study was to search for other mutations in selected...
1992年,PD-1受体基因(programmed cell death 1 receptor gene)在程序性凋亡的T细胞杂交瘤中被检测出 [1] 。对小鼠Pdcd1-/-突变体的自身免疫表型研究揭示了PD-1具有重要的负调控功能 [2] [3] 。在2000年和2001年,鉴定得到了PD-1的配体,从而在理解PD-1及其配体的功能方面取得了长足的进展 [4] [5] [6]...
近日,北京大学天然药物及仿生药物全国重点实验室吕万良教授团队在著名学术期刊Bioactive Materials在线发表了题为“Gene engineered exosome reverses T cell exhaustion in cancer immunotherapy”的研究论文,研究针对肿瘤免疫检查点治疗中免疫耗竭与免疫逃逸的关键科学问题,通过基因工程技术,重组构建了一种新型基因工程化PD1蛋白...
Site-directed mutagenesis of the putative HAP2/HAP3/HAP4 binding site at 204 relative to the ATG start codon showed that this element was required for full derepression of the LPD1 gene on non-fermetable substrates. 展开 关键词: Saccharomyces cerevisiae Lipoamide dehydrogenase HAP activation ...
Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 11, 141–151 (1999). This study describes the development of the first Pdcd1 -knockout mouse. Characterization of Pdcd1 -knockout in the C57BL/6 background ...
近日,北京大学天然药物及仿生药物全国重点实验室吕万良教授团队在著名学术期刊《Bioactive Materials》在线发表了题为“Gene engineered exosome reverses T cell exhaustion in cancer immunotherapy”的研究论文,研究针对肿瘤免疫检查点治疗中免疫耗竭与免疫逃逸的关键科学问题,通过基因工程技术,重组构建了一种新型基因工程化PD...
近日,北京大学天然药物及仿生药物全国重点实验室吕万良教授团队在著名学术期刊《Bioactive Materials》在线发表了题为“Gene engineered exosome reverses T cell exhaustion in cancer immunotherapy”的研究论文,研究针对肿瘤免疫检查点治疗中免疫耗...
Ishida Y,Agata Y,Shibahara K,et al.Induced expression of PD-1,a novel member of the immunoglobulin genesuperfamily,upon programmed cell death [J].EMBO J,1992,11( 11) : 3887-3895. Yao S,Chen L.PD-1 as an immune modulatory receptor[J].Cancer J,2013, 20( 4) : 262. Zhang X,Schwar...