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J.L.; Han, J.-Y.; Molina, J.; Kim, J.-H.; Arvis, C.D.; Ahn, M.-J.; et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): A randomi...
[3] Herbst, R.S., P. Baas, D.W. Kim, et al., Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet. 2016, 387(10027): 1540-1550. [4] Paz-Ares, L., D. Vicente, A. Tafre...
1.Paz-Ares L, Luft A, Vicente D, et al. Pembrolizumab plus Chemotherapy for Squamous Non-Small-Cell Lung Cancer. N Engl J Med. 2018;379(21):2040-2051. doi:10.1056/NEJMoa1810865 2.Reck M, Rodríguez-Abreu D, Robinson AG, et al. Pembrolizumab versus Chemotherapy for PD-L1-Positive Non...
2 Kazutaka Hosoya1, Daichi Fujimoto, Takeshi Morimoto, et al. Clinical factors associated with shorter durable response, and patterns of acquired resistance to first-line pembrolizumab monotherapy in PD-L1-positive non-smallcell lung cancer patients: a retrospective multicenter study[J]. BMC Cancer,...
免疫组织化学(immunohistochemistry,IHC,简称免疫组化)检测是评估肿瘤组织PD-L1表达状态的一种有效且最常用方法,广泛应用于包括非小细胞肺癌(non-small cell lung cancer, NSCLC)等在内的多种恶性肿瘤中,以识别或辅助预测可能从免疫治疗中获益的患者。 为更好地指导临床检测,中国抗癌协会肿瘤病理专业委员会肺癌学组...
[4]Reck M, Rodríguez-Abreu D, Robinson AG, er al. Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer[J]. N Engl J Med, 2016, 375(19):1823-1833.[5]Herbst RS, Giaccone G, de Marinis F, et al. Atezolizumab for First-Line Treatment of PD-L1-Selected ...
This disclosure provides a method for treating a subject afflicted with a PD-L1 positive non-squamous non-small cell lung cancer (NSCLC). The method comprises administering to the subject a therapeutically effective amount of an anti-PD-1 anti-body or anti-PD-L1 antibody. In some embodiments,...
[5]Nishio M, Takahashi T, Yoshioka H, et al. Keynote-025: Phase 1b Study of Pembrolizumab in Japanese Patients with Previously Treated Programmed Death Ligand 1-Positive Advanced Non-Small-Cell Lung Cancer [J].Cancer scie...
CPS:联合阳性评分(Combined Positive Score) 定义:每100个肿瘤细胞中 PD-L1染色的肿瘤细胞和肿瘤相关的免疫细胞数之和,即CPS=(PD-L1膜染色阳性肿瘤细胞+PD-L1膜染色阳性肿瘤相关免疫细胞(淋巴细胞、巨噬细胞))/总肿瘤细胞数 x100。 IPS免疫细胞阳性比例分数(Immune cell Proportion Score)定义:任何强度PD-L1膜和...