在基底样乳腺癌细胞中，非糖基化的PD-L1可以被糖原合成酶激酶3β(glycogen synthase kinase 3 beta，GSK3β)磷酸化并诱导β-TrCP对PD-L1的磷酸化依赖性蛋白酶体降解[26]。STIP1同源性和包含U-box蛋白1(STIP1 homologous and U box containing protein 1，STUB1)具有泛素连接酶E3活性，可以降解细胞内的PD-L1。
et al. Increased PD-L1 expression in radioresistant HNSCC cell lines after irradiation affects cell proliferation due to inactivation of GSK-3beta. Oncotarget 10, 573–583 (2019). Article PubMed PubMed Central Google Scholar Cheon, H., Holvey-Bates, E. G., McGrail, D. J. & Stark, G...
A second cohort of tumors obtained from Caris Life Sciences (n=73,324) was interrogated for GSK-3β genomic alterations and PD-L1 expression (assessed via SP-142 antibody on tumor cells, cutoff used was 5%). Chi-square test was used to assess significance between PD-L1 expression of GSK3...
epigenetic and genetic alterations. ERO1α, endoplasmic reticulum oxidoreductase; IFN-γ, Interferon-γ; IL-6, Interleukin-6; JAK, Janus Kinase; EGF, Epidermal growth factor; GSK3β, Glycogen synthase kinase 3β; B3GNT3, β-1,3-N-acetylglucosaminyltransferase...
在基底样乳腺癌细胞中,非糖基化的PD-L1可以被糖原合成酶激酶3β(glycogen synthase kinase 3 beta,GSK3β)磷酸化并诱导β-TrCP对PD-L1的磷酸化依赖性蛋白酶体降解[26]。STIP1同源性和包含U-box蛋白1(STIP1 homologous and U box containing protein 1,ST...
在基底样乳腺癌细胞中,非糖基化的PD-L1可以被糖原合成酶激酶3β(glycogen synthase kinase 3 beta,GSK3β)磷酸化并诱导β-TrCP对PD-L1的磷酸化依赖性蛋白酶体降解[26]。STIP1同源性和包含U-box蛋白1(STIP1 homologous and U box containing protein 1,ST...
[9]. Another method is using biomarkers to predict response to therapy [13,14]. Recent work has also suggested that GSK3 inhibitors can enhance effects of immunotherapy [15].Though these results have been encouraging, several challenges remain, including the mitigation of autoimmune effects and ...
Interestingly, PD-L1 knockdown reduced α-SMA reporter activity induced by TGF-β in HLFs, suggesting that PD-L1 might act as a co-factor of Smad3 to promote target gene expression. TGF-β treatment also phosphorylates GSK3β and upregulates β-catenin protein levels. Inhibiting β-catenin ...
在基底样乳腺癌细胞中,非糖基化的PD-L1可以被糖原合成酶激酶3β(glycogen synthase kinase 3 beta,GSK3β)磷酸化并诱导β-TrCP对PD-L1的磷酸化依赖性蛋白酶体降解[26]。STIP1同源性和包含U-box蛋白1(STIP1 homologous and U box containing protein 1,STUB1)具有泛素连接酶E3活性,可以降解细胞内的PD-L1。
在基底样乳腺癌细胞中,非糖基化的PD-L1可以被糖原合成酶激酶3β(glycogen synthase kinase 3 beta,GSK3β)磷酸化并诱导β-TrCP对PD-L1的磷酸化依赖性蛋白酶体降解[26]。STIP1同源性和包含U-box蛋白1(STIP1 homologous and U box containing protein 1,ST...