PI3K-AKT-GSK3 beta-CREB signaling pathwayThe medial prefrontal cortexWortmanninBACKGROUND: Alcohol abuse and anxiety disorders often occur concurrently, but their underlying cellular mechanisms remain unclear. Neuroadaptation within the medial prefrontal cortex (mPFC) have been implicated in the molecular ...
(R)- (+)-alpha-Lipoic acid protected NG108-15 cells against H2O2-induced cell death through PI3K- Akt/GSK-3beta pathway and suppression of NF-kappabeta-cytokines. Drug Des Devel Ther. 2014; 8:1765-1780.Kamarudin M. N., Mohd Raflee N. A., Hussein S. S., Lo J. Y...
(2005). Insulin-like growth factor-I inhibits dexamethasone-induced proteolysis in cultured L6 myotubes through PI3K/Akt/GSK-3beta and PI3K/Akt/mTOR-dependent mechanisms. Int J Biochem Cell Biol 37: 2207-2216.Li BG, Hasselgren PO, and Fang CH. Insulin-like growth factor-I inhibits ...
Dexamethasone (Dex), a type of glucocorticoids (GCs), induces apoptosis of osteoblasts and leads to the occurrence of non-traumatic osteonecrosis. This study aimed to explore the effects of phosphatidylinositol 3-kinase/Protein kinase 3 (PI3K/AKT) and glycogen synthase kinase 3 beta (GSK3 beta)...
TDCPP protects cardiomyocytes from H2O2-induced injuries via activating PI3K/Akt/GSK3 beta signaling pathwayTDCPPCardiomyocytesOxidative stressCalcium overloadApoptosisTris (1, 3-dichloro-2-propyl) phosphate (TDCPP) is a major type of organophosphorus flame retardants, and long-term exposure to TDCPP to...
PI3K-AKT-GSK3 beta-CREB signaling pathwayThe medial prefrontal cortexWortmanninBackground: Alcohol abuse and anxiety disorders often occur concurrently, but their underlying cellular mechanisms remain unclear. Neuroadaptation within the medial prefrontal cortex (mPFC) have been implicated in the molecular ...
These results suggest that Prx II regulated apoptosis of keratinocytes via the PI3K/AKT/GSK3 & beta; signaling axis. Furthermore, treatment with the Prx II inhibitor Conoidin A significantly alleviated psoriatic symptoms in IMQ model mice. These findings have important implications for developing ...
NR3C1 protein regulated transcription of PI3K-related genes in ALL cells, which diminished PIK3CD transcription and increased mRNA level of PIK3R6, PIK3R5, PIK3R2, AKT3 and GSK3尾. In addition, NR3C1 increased transcription of pro-apoptotic genes, BCL2L11 (encoding Bim protein), BMF and ...
Infiltrating mast cells promote renal cell carcinoma angiogenesis by modulating PI3K AKT GSK3β AM signalingOncogene advance online publication, January 23 2017. doi:10.1038/onc.2016.44 ...doi:10.1038/onc.2016.442Y ChenC LiH XieY FanZ Yang
Ginsenoside Rb1Dermal papilla cellsPI3K/AKT/GSK-3 beta signaling pathwayAims: Hair follicles play a critical role in the process of hair growth. The dermal papilla cells (DPCs) are an important component in the hair follicle regeneration and growth. This study investigated the effects of ...