在基底样乳腺癌细胞中，非糖基化的PD-L1可以被糖原合成酶激酶3β(glycogen synthase kinase 3 beta，GSK3β)磷酸化并诱导β-TrCP对PD-L1的磷酸化依赖性蛋白酶体降解[26]。STIP1同源性和包含U-box蛋白1(STIP1 homologous and U box containing protein 1，STUB1)具有泛素连接酶E3活性，可以降解细胞内的PD-L1。
et al. Increased PD-L1 expression in radioresistant HNSCC cell lines after irradiation affects cell proliferation due to inactivation of GSK-3beta. Oncotarget 10, 573–583 (2019). Article PubMed PubMed Central Google Scholar Cheon, H., Holvey-Bates, E. G., McGrail, D. J. & Stark, G...
A second cohort of tumors obtained from Caris Life Sciences (n=73,324) was interrogated for GSK-3β genomic alterations and PD-L1 expression (assessed via SP-142 antibody on tumor cells, cutoff used was 5%). Chi-square test was used to assess significance between PD-L1 expression of GSK3...
epigenetic and genetic alterations. ERO1α, endoplasmic reticulum oxidoreductase; IFN-γ, Interferon-γ; IL-6, Interleukin-6; JAK, Janus Kinase; EGF, Epidermal growth factor; GSK3β, Glycogen synthase kinase 3β; B3GNT3, β-1,3-N-acetylglucosaminyltransferase...
在基底样乳腺癌细胞中,非糖基化的PD-L1可以被糖原合成酶激酶3β(glycogen synthase kinase 3 beta,GSK3β)磷酸化并诱导β-TrCP对PD-L1的磷酸化依赖性蛋白酶体降解[26]。STIP1同源性和包含U-box蛋白1(STIP1 homologous and U box containing protein 1,ST...
在基底样乳腺癌细胞中,非糖基化的PD-L1可以被糖原合成酶激酶3β(glycogen synthase kinase 3 beta,GSK3β)磷酸化并诱导β-TrCP对PD-L1的磷酸化依赖性蛋白酶体降解[26]。STIP1同源性和包含U-box蛋白1(STIP1 homologous and U box containing protein 1,ST...
Recent work has also suggested that GSK3 inhibitors can enhance effects of immunotherapy [15].Though these results have been encouraging, several challenges remain, including the mitigation of autoimmune effects and how to overcome drug resistance. Current Antibody Drug Development Drug Company PD-1 ...
在基底样乳腺癌细胞中,非糖基化的PD-L1可以被糖原合成酶激酶3β(glycogen synthase kinase 3 beta,GSK3β)磷酸化并诱导β-TrCP对PD-L1的磷酸化依赖性蛋白酶体降解[26]。STIP1同源性和包含U-box蛋白1(STIP1 homologous and U box containing protein 1,STUB1)具有泛素连接酶E3活性,可以降解细胞内的PD-L1。
3. Some specific drugs or a combination of these drugs with PD-L1/PD-1 blockade inhibitors can effectively enhance antitumor immunotherapy. Open questions 1. How does GSK3β or AMPK induce the extracellular fragment of PD-L1 phosphorylation?
在基底样乳腺癌细胞中,非糖基化的PD-L1可以被糖原合成酶激酶3β(glycogen synthase kinase 3 beta,GSK3β)磷酸化并诱导β-TrCP对PD-L1的磷酸化依赖性蛋白酶体降解[26]。STIP1同源性和包含U-box蛋白1(STIP1 homologous and U box containing protein 1,ST...