AIRE是由545个氨基酸组成的一种具有转录活化潜能的DNA结合蛋白,从N末端开始,AIRE由一个可能介导DNA结合的半胱氨酸天冬氨酸蛋白酶募集结构域(caspase recruitment domain, CARD)、一个核定位序列(nuclear localization sequences, NLS)、一个SAND结构域、两个植物同源结构域(plant homeodomain, PHD)锌指、一个脯氨酸富集...
结构域改组实现的亲和力成熟。cdr和/或框架残基的随机诱变描述于例如以下:barbas等人,《美国国家科学院院刊》91:3809-3813(1994);schier等人,《基因(gene)》169:147-155(1995);yelton等人,《免疫学杂志》155:1994-2004(1995);jackson等人,《免疫学杂志》154(7):3310-9(1995);以及hawkins等人,《分子生物学杂志...
AIRE是由545个氨基酸组成的一种具有转录活化潜能的DNA结合蛋白,从N末端开始,AIRE由一个可能介导DNA结合的半胱氨酸天冬氨酸蛋白酶募集结构域(caspase recruitment domain, CARD)、一个核定位序列(nuclear localization sequences, NLS)、一个SAND结构域、两个植物同源结构域(plant homeodomain, PHD)锌指、一个脯氨酸富集...
[27] Negrao MV, Lam VK, Reuben A, et al. PD-L1 Expression, Tumor Mutational Burden, and Cancer Gene Mutations Are Stronger Predictors of Benefit from Immune Checkpoint Blockade than HLA Class I Genotype in Non-Small Cel...
[27] Negrao MV, Lam VK, Reuben A, et al. PD-L1 Expression, Tumor Mutational Burden, and Cancer Gene Mutations Are Stronger Predictors of Benefit from Immune Checkpoint Blockade than HLA Class I Genotype in Non-Small Cell Lung Cancer. J Thorac Oncol 2019. [Epub ahead of print]. ...
需要个体化靶向药物、免疫药物、化疗药物治疗的实体瘤患者;2.典型驱动基因突变为阴性,寻求更多靶向用药机会的实体瘤患者;3.原发灶不明、全身多发肿瘤或转移的实体瘤患者;4.耐药后,寻求耐药机制及有效药物的实体瘤患者;5.有肿瘤家族史的实体瘤患者;肿瘤用药基因检测升级版 (组织962gene+PD-L1或+TME)品牌:CGENE-...
Interferon-stimulated gene 15 TMUB1: Transmembrane and ubiquitin-like domain-containing protein 1 OS: Overall survival DFS: Disease-free survival IHC: Immunohistochemistry CTL: Cytotoxic T lymphocyte AMPK: AMP-activated protein kinase ERAD: ER-associated protein degradation ...
the addition of anti-PD-L1 caused an increase in CD8+T cell infiltration and higher expression of immune-related gene signatures. Four of the first 22 patients were progression free at 24 weeks in the first stage of the trial, warranting expansion of the trial according to the Simon’s two...
View recombinant Rabbit Monoclonal anti-PD-L1 Antibody (2096A) [Allophycocyanin] (MAB90782APC). Validated Applications: Flow, IHC, CyTOF-ready. Validated Species: Mouse.
(Fig.4c, Supplementary Fig.8b). To study the effect of LAIR2 on LAIR1-induced CD8+T cell exhaustion, we generated 344SQ cells that constitutively express human LAIR2, as mice do not possess the LAIR2 gene26,41. LAIR2 secretion into the conditioned media was validated by ELISA (...