胃癌靶标从DisGeNET数据库和GeneCards数据库下载并将它们与预测靶点合并.通过venn图获得药物作用靶点与疾病基因的交集.使用STRING数据库筛选的核心靶点进行了分析和处理,从中获得了这些蛋白质之间的相关作用关系,导入Cytoscape3.7.1软件,构成PPI网络图.使用Cytoscape3.7.2插件CytoNCA分析PPI网络中的连接性程度,作为核心靶点....
Methods:In this study, we collected gene expression profiles and clinical information in The Cancer Genome Map (TCGA) database and two independent Group on Earth Observations (GEO) datasets. Gene interaction information was obtained from ENCORI database. Based on these databases, we analyzed the e...
Therefore, biomarkers that can effectively predict the efficacy of PD-1/PD-L1 are crucial for therapeutic strategies. A substantial number of research studies on the prediction of gene mutation have been carried out. Mu et al. [44] applied deep learning models to predict EGFR mutation statuses ...