Full Name CD274 molecule Synonyms CD274, PD-L1, PDCD1 ligand 1, PD L1, hPD-L1 Calculated Molecular Weight 290 aa, 33 kDa Observed Molecular Weight 45-50 kDa GenBank Accession Number BC074984 Gene Symbol PD-L1 Gene ID (NCBI) 29126 RRID AB_2881052 Conjugate Unconjugated Form Liquid Purific...
Full Name CD274 molecule Synonyms CD274, PD-L1, PD L1, hPD-L1, B7-H1 Calculated Molecular Weight 290 aa, 33 kDa Observed Molecular Weight 45-50 kDa, 33 kDa GenBank Accession Number BC074984 Gene Symbol PD-L1 Gene ID (NCBI) 29126 RRID AB_2756526 Conjugate Unconjugate...
Full Name CD274 molecule Calculated Molecular Weight 290 aa, 33 kDa Observed Molecular Weight 45-50 kDa, 33 kDa GenBank Accession Number BC074984 Gene Symbol PD-L1 Gene ID (NCBI) 29126 RRID AB_2756526 Conjugate Unconjugated Form Liquid Purification Method Protein A purification UNIPROT ID Q9NZ...
Full size image Roles of PD-1/PD-L1 in transplantation and autoimmune diseases The PD-1/PD-L1 signaling pathway is critical in autoimmune diseases, viral infections, transplantation and tumor immunity [32, 33]. Under a normal physiologic state, PD-1/PD-L1 signaling can effectively inhibit the...
Full Name CD274 molecule Calculated Molecular Weight 290 aa, 33 kDa Observed Molecular Weight 45-56 kDa, 65-70 kDa GenBank Accession Number BC074984 Gene Symbol PD-L1 Gene ID (NCBI) 29126 RRID AB_10597552 Conjugate Unconjugated Form Liquid Purification Method Antigen affinity purification UNIPROT...
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Full size image Double-staining IHC analysis revealed that CAFs expressed PlGF/VEGF receptors (Fig.2g), and NRP1+CAF, VR1+CAF, and VR2+CAF were strongly negatively correlated with patient prognosis (r = −0.7199,p < 0.001;r = −0.6898,p < 0.001;r = −0.7131...
host : mouse conjugate : APC clone name : 29E.2A3 reactivity : human,mouse application : western blot,flow cytometry more info or order: BioLegend product webpage citations: 51 Published Application/Species/Sample/DilutionReference flow cytometry; human;loading ...; fig 1c ...
Full size image To suppress residual T cell activity, we introduced PD-L1 and PD-L2 molecules to directly inhibit T cell response. In addition to this, we introduced RapaCasp9 as a safety switch [21]. RapaCasp9 is a single protein composed of the FRB domain of mTOR, FKBP12, and the...
The current paradigm is that full activation of T cells requires at least 2 signals upon contact with antigen-presenting cells (APCs) [1, 2]. Signal 1 is delivered through the interaction of the T cell receptor (TCR) and a specific antigenic peptide associated with an MHC (major ...