Human PD-L1 Dimer Kit用于检测PD-L1的二聚化，可快速、高通量筛选使PD-L1产生二聚的化学小分子。试剂盒中有PD-L1-Eu(标记荧光供体Eu，PD-L1-Eu)，以及PD-L1-A2(标记荧光受体A2，PD-L1-A2)。当PD-L1发生二聚化时，PD-L1-Eu和PD-L1-A2距离靠近，可发生荧光共振能量转移(FRET)。使用320 nm的激发光激...
Human PD-L1 Dimer Kit用于检测PD-L1的二聚化,可快速、高通量筛选使PD-L1产生二聚的化学小分子。试剂盒中有PD-L1-Eu(标记荧光供体Eu,PD-L1-Eu),以及PD-L1-A2(标记荧光受体A2,PD-L1-A2)。当PD-L1发生二聚化时,PD-L1-Eu和PD-L1-A2距离靠近,可发生荧光共振能量转移(FRET)。使用320 nm的激发光激发Eu...
Targeting the PD-L1 dimer inhibits PD-L1 function PD-L1 can form homodimers and tetramers, and its complex glycosylation is linked to the homodimeric structure of its intracellular domain [190]. Natural compounds such as capsaicin, 6-gingerol, and curcumin may block the PD-1/PD-L1 interactio...
The phosphorylated STAT1 protein forms a STAT1 dimer that binds to the promoter region of the PDL1 gene. In this way, STAT1 dimerization promotes the transcription of PD-L1 gene and expresses PD-L1 protein.(B) IL-6 can also induce PD-L1 expression through STAT3 phosphorylation via the JAK ...
NF-κB is a homologous or heterologous dimer formed by members of the Rel family, and it plays a key role in cell growth, apoptosis, and immune responses through transcriptional regulation. LMP1 may induce PD-L1 expression in natural killer/T-cell lymphoma cells through regulation of the MAPK...
(cGAMP). Stimulated by cGAMP, STING changes from monomer to dimer and translocates from ER to perinuclear microsome. Then, STING recruits and phosphorylates TBK1, which further activates downstream IRF3 and upregulates IFN-I [257,258,259]. Besides, STING also increases IFN-I by activating NF-...
It antagonizes the PD-1/PD-L1 interaction by binding to the PD-L1 dimer, obstructing PD-1 signaling. This compound is utilized in research pertaining to lung cancer and melanoma [1]. PD-1/PD-L1 $90 In Stock Size QTY Related Compound Libraries of "BMS-1166" Hematonosis Compound Library...
(cGAMP). Stimulated by cGAMP, STING changes from monomer to dimer and translocates from ER to perinuclear microsome. Then, STING recruits and phosphorylates TBK1, which further activates downstream IRF3 and upregulates IFN-I [257,258,259]. Besides, STING also increases IFN-I by activating NF-...
It antagonizes the PD-1/PD-L1 interaction by binding to the PD-L1 dimer, obstructing PD-1 signaling. This compound is utilized in research pertaining to lung cancer and melanoma [1]. PD-1/PD-L1 $90 In Stock Size QTY Contact us for more batch information Resource Download DataSheet SDS...