Atezolizumab: A PD-L1-Blocking Antibody for Bladder Cancer. Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res. 2017;23:1886-1890.Inman BA, Longo TA, Ramalingam S, Harrison MR. Atezolizumab: A PD-L1-blocking antibody for bladder cancer. Clin Cancer Res 2017;23:1886-90...
Atezolizumab: A PD-L1-Blocking Antibody for Bladder Cancer. Atezolizumab (Tecentriq, MPDL3280A) is an Fc纬R-binding deficient, fully humanized, IgG1 monoclonal antibody designed to interfere with the binding of PD-L1 ligand to its two receptors, PD-1 and B7.1. By blocking the PD-L1/PD-...
The accumulation of senescent cells is a major cause of age-related inflammation and predisposes to a variety of age-related diseases1. However, little is known about the molecular basis underlying this accumulation and its potential as a target to ameliorate the ageing process. Here we show that...
MIH1 is reported to be a blocking antibody.^M^MApplications Reported: This MIH1 antibody has been reported for use in flow cytometric analysis.^M^MApplications Tested: This MIH1 antibody has been pre-titrated and tested by flow cytometric analysis of stimulated human peripheral bl...
MIH5 is reported to be a blocking antibody.Applications Reported: This MIH5 antibody has been reported for use in flow cytometric analysis.Applications Tested: This MIH5 antibody has been tested by flow cytometric analysis of mouse splenocytes. This may be used at less than or...
Interestingly, the anti-PD-L1 antibody increased the serum level of sPD-L1. In vitro, blocking of PD-L1 on the surface of mouse aortic endothelial cells with anti-PD-L1 antibody stimulated the activation and secretion of cytokines, including IFN-γ, PF, GNLY, Gzms B and LTA, from ...
blocking the PD-1/PD-L1 interaction, they have specific shortcomings as therapeutics. Poor tissue/tumor penetrance of antibody drugs due to their large size can be problematic, especially when targeting PD-1/PD-L1 signaling as PD-1-expressing T cells are found infiltrated within the solid ...
Anti-Mouse CD274/PD-L1/B7-H1 Antibody ABS0535 一抗 价格: ￥2219/支 产品详情:Product Name Anti-Mouse CD274/PD-L1/B7-H1 Antibody ABS0535 Host Species Mouse Applications Blocking, ELISA, FCM Species ... 用途:供科研使用 用途:供科研使用 货号:MV974013 品牌:abinScience 产地:France 抗体名:Ant...
PD-L1 Antibody (PA5-20343) in ICC/IF Immunofluorescence analysis of CD274 was performed using log phase THP-1 cells treated with PMA (200 ng/mL, 6 hours), IFN gamma (20 ng/mL) and LPS (100 ng/mL), 18hours. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized...
(TCR)-driven stop signals depended on continued interactions between PD-1 and its ligand, PD-L1, as antibody blockade of PD-1 or PD-L1 resulted in lower T cell motility, enhanced T cell–DC contacts and caused autoimmune diabetes. Blockade of the immunomodulatory receptor CTLA-4 did not ...