A Deep Eutectic Solvent, choline chloride/glycerol (1 : 2 mol mol1), proved to be an effective and sustainable reaction medium to promote telescoped, one‐pot Mizoroki‐Heck cross‐coupling/reduction processes between 2,3‐dihydrofuran or 3,4‐dihydro‐2H‐pyran and several (...
This distinctive single-electron transfer mediated reaction pathway resolves a longstanding challenge in traditional two-electron based Pd-catalyzed Mizoroki–Heck cross-coupling with alkyl electrophiles, wherein the β-hydride elimination is involved in the formation of both the desired product and ...
Pd-catalyzed reductive cross-coupling in the construction of Csp2−Csp3 bond. The Ullmann reaction, initially reported in 1901 [19], is one of the most efficient reductive cross-coupling in constructing C−C bonds between two aryl halides using stoichiometric copper. Ni(0)-catalyzed reductive...
we speculated that a Pd–D insertion process might be involved in the reaction, which would lead to deuterium enriching at the terminus of the alkenes
Keywords: Mizoroki-Heck reaction; Pd-catalyzed; fluorine; cross-coupling; alkenes; halides 1. Introduction The palladium-catalyzed carbon-carbon cross-coupling of an aryl or vinyl halide and an alkene in the presence of a base is referred as the "Mizoroki-Heck reaction" [1–6]. The reaction...
The reaction mechanism was also proposed, which included two catalytic cycles, one of which was started from Pd(0) and included oxidative addition, deprotonation, and reductive elimination, resulting in theformation of 2-bromo-1-tosyl-1H-indole. The latter entered the second cycle that also ...
Fast and Regioselective Heck Couplings with N-Acyl-N-vinylamine Derivatives Highly regioselective Heck couplings of aryl triflates with N-acyl-N-vinylamines lacking an N-alkyl substituent were achieved with reaction times of approx... AL Hansen,T Skrydstrup - 《Journal of Organic Chemistry》 被引...
Highly enantioselective palladium-catalyzed dearomative reductive Heck reaction and domino Heck鈥揝uzuki reaction of 2-CF3-indoles have been developed. Using Pd(OAc)2/(R)-Synphos as the catalyst and Et3SiH as a hydride source, a variety of indolines bearing a 2-trifluoromethyl quaternary stereo...
Hydroarylation of olefins catalyzed by palladium (reductive Heck reaction) is an important method for C-C bond formation, and has been widely used in organic synthesis. In recent years, the enantioselective catalytic hydroarylation of olefins has attracted an increasing amount of attention. However,...
We report herein a palladium-catalyzed ligand-promoted asymmetric dearomatization of indoles via the decarbonylation of thioesters and the subsequent reductive Heck reaction. This protocol provides a facile and efficient way to construct an aza-quaternary stereocenter at the C2 position of indolines. A...