PD‐1 ligationOur understanding of programmed cell death 1 (PD-1) biology is limited due to technical difficulties in establishing reproducible, yet simple, in vitro assays to study PD-1 signaling in primary human T cells. The protocols in this article were refined to test the consequences of...
PD-1受体有一个第二配体,PD-L2(也称为B7-DC或CD273),是优先地被抗原-提呈细胞表达[3]。在肿瘤模型中,PD-1负性地调节在肿瘤内被表达的PD-L1的结扎[ligation]后T-细胞应答的效应器相[4]。曾假设阻断肿瘤内PD-1和PD-L1间相互作用的抗体可能优先地释放比群体...
PD-1 (programmed death-1), also called CD279, is a receptor expressed upon activation on innate and adaptive immune cells and is encoded by the genePdcd1. It recognized two ligands, PD-L1 (programmed death-ligand 1) and PD-L2 (programmed death-ligand 2). Upon ligation of its ligand, ...
[8] Chemnitz J M, Parry R V, Nichols K E,et al. SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation [J]. The Journal of Immunology, 2004, 173(2): ...
Phenotypic and transcriptional profiling of regulatory T (Treg) cells at homeostasis reveals that T cell receptor activation promotes Treg cells with an effector phenotype (eTreg) characterized by the production of interleukin-10 and expression of the in
6.J. Zhao et al., Corosolic acid inhibits tumour growth without compromising associating liver partition and portal vein ligation-induced liver regeneration in rats. Ann Med 54, 1188-1201 (2022). 往期推荐 1.病理IHC专题|如何提高...
During activation, T cells undergo metabolic reprogramming, which imprints distinct functional fates. We determined that on PD-1 ligation, activated T cells are unable to engage in glycolysis or amino acid metabolism but have an increased rate of fatty acid β-oxidation (FAO). PD-1 promotes FAO...
PD-1 ligation also led to differential phosphorylation of serine and threonine sites within proteins regulating T cell activation, gene expression, and protein translation. In silico predictions revealed that kinase/substrate relationships engaged downstream of PD-1 ligation. These insights uncover the ...
In recent years, cancer immunotherapy has emerged as an exciting cancer treatment. Immune checkpoint blockade brings new opportunities for more researchers and clinicians. Programmed cell death receptor-1 (PD-1) is a widely studied immune checkpoint, and
It has been demonstrated that PD-1 ligation inhibited PI3K activity and downstream AKT activation, whereas CTLA-4 only inhibited AKT activation but did not influence PI3K activity. As CTLA-4 and PD-1 regulate immune response through a nonredundant distinct mechanism, it was possible to achieve ...