PD-1受体有一个第二配体,PD-L2(也称为B7-DC或CD273),是优先地被抗原-提呈细胞表达[3]。在肿瘤模型中,PD-1负性地调节在肿瘤内被表达的PD-L1的结扎[ligation]后T-细胞应答的效应器相[4]。曾假设阻断肿瘤内PD-1和PD-L1间相互作用的抗体可能优先地释放比群体...
5.J. Zhang et al., ITGAL as a Prognostic Biomarker Correlated With Immune Infiltrates in Gastric Cancer. Front Cell Dev Biol 10, 808212 (2022). 6.J. Zhao et al., Corosolic acid inhibits tumour growth without compromising ass...
[8] Chemnitz J M, Parry R V, Nichols K E,et al. SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation [J]. The Journal of Immunology, 2004, 173(2): ...
In addition, compared to unstimulated cells and to cells stimulated via the TCR alone, 伪CD3 stimulation in the presence of PD-1 ligation led to significant dephosphorylation of proteins involved in cytoskeletal organization and cellular adhesion. Surprisingly, we observed increased S/T phosphorylation ...
Phenotypic and transcriptional profiling of regulatory T (Treg) cells at homeostasis reveals that T cell receptor activation promotes Treg cells with an effector phenotype (eTreg) characterized by the production of interleukin-10 and expression of the in
During activation, T cells undergo metabolic reprogramming, which imprints distinct functional fates. We determined that on PD-1 ligation, activated T cells are unable to engage in glycolysis or amino acid metabolism but have an increased rate of fatty acid β-oxidation (FAO). PD-1 promotes FAO...
In recent years, cancer immunotherapy has emerged as an exciting cancer treatment. Immune checkpoint blockade brings new opportunities for more researchers and clinicians. Programmed cell death receptor-1 (PD-1) is a widely studied immune checkpoint, and
PD-1 ligation also led to differential phosphorylation of serine and threonine sites within proteins regulating T cell activation, gene expression, and protein translation. In silico predictions revealed that kinase/substrate relationships engaged downstream of PD-1 ligation. These insights uncover the ...
Blockade of the PD-1/PD-Ll ligation using antibodies to PD-Ll has been shown to restore and augment T cell activation in many systems[1]. Kinase Assay All binding studies are performed in an HTRF assay buffer consisting of dPBS supplemented with 0.1% (with v) bovine serum albumin and ...
[2]Chemnitz, J.M.Parry, R.V.Nichols, K.E.June, C.H. and Riley, J.L. (2004) SHP-1 and SHP-2 Associate with Im- munoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 Upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation. The Journal ...