In this study, by using PD-1/PD-L1 and CTLA-4 inhibitors, we aim to evaluate the therapeutic effects of these ICIs on silica-induced mouse pulmonary fibrosis. 2. Materials and methods 2.1. Animal model Male C57BL/6 mice (6–8 weeks of age; 18–22 g of weight) were provided by ...
These interactions lead to inhibitory signals via the PD-L1/PD-1 axis, which suppresses excessive CNS inflammation by inhibiting microglial activation (Figure 4B, Expression regulatory pathway). PD-L1 overexpression in APCs inhibited the immune responses of autoreactive T cells in EAE, whereas PD-...
As previously reported, tumour-derived GDF-15 inhibits the LFA-1–ICAM-1 axis in T cells3, impairing T cell migration into tumour tissue. Neutralization of GDF-15 enhances T cell infiltration and efficacy of immune checkpoint blockade in mouse GDF-15-expressing tumour models3. Sequential biopsies...
As previously reported, tumour-derived GDF-15 inhibits the LFA-1–ICAM-1 axis in T cells3, impairing T cell migration into tumour tissue. Neutralization of GDF-15 enhances T cell infiltration and efficacy of immune checkpoint blockade in mouse GDF-15-expressing tumour models3...
PD-1/PD-L1 is involved in immune regulation and in maintaining the immune tolerance to autoantigens via a mechanism that is likely to be associated with the inhibition of T-cell hyperactivation and cytokine secretion [20]. Inhibiting the PD-1/PD-L1 axis can reverse the immunosuppressive target...
Camrelizumab combined with apatinib in patients with first-line platinum-resistant or PD-1 inhibitor resistant recurrent/metastatic nasopharyngeal carcinoma: a single-arm, phase 2 trial Li Yuan, Guo-Dong Jia, Xiao-Fei Lv, Si-Yi Xie, Shan-Shan Guo, Da-Feng Lin, Li-Ting Liu, Do...
Lower respiratory tract microbiome constitutes a unique immune microenvironment for advanced non-small cell lung cancer as one of dominant localized microb
The PDL1-PD1 axis converts human TH1 cells into regulatory T cells. Sci Transl Med. 2011;3(111):111ra20. Article Google Scholar Wang L, Pino-Lagos K, de Vries VC, Guleria I, Sayegh MH, Noelle RJ. Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ ...
Yet, the physiological role of the PD-1/PDL-1 axis in T cell homeostasis is still poorly understood. Herein, we show that under steady-state conditions, the absence of PD-1 signaling led to a preferential expansion of CD8+ T cells in the liver. These cells exhibit an oligoclonal T ...
Although the various damages to the allograft (including acute or chronic rejection) resulting in interstitial fibrosis/tubular atrophy (IF/TA) are not unequivocal, it is widely accepted that the incidence and severity of acute rejection is associated with chronic organ damage and eventually allograft...